Results 91 to 100 of about 102,620 (291)

Evolution of supraglacial lakes over the pan-Antarctic ice sheet between 2014 and 2022: Assessment and the control factors

Advances in Climate Change Research
Widespread supraglacial lakes (SGLs) across the Antarctic surface can accelerate land ice flow and be linked to ice shelf disintegration, further affecting sea-level rise projections. However, previous studies usually focused on SGLs at regional scale or
Xiao-Yi Shen, Chang-Qing Ke, Hai-Li Li, Yu Cai, Yao Xiao, Meng-Meng Li   +5 more
doaj   +1 more source

Intercomparison of Antarctic ice-shelf, ocean, and sea-ice interactions simulated by MetROMS-iceshelf and FESOM 1.4 [PDF]

, 2018
An increasing number of Southern Ocean models now include Antarctic ice-shelf cavities, and simulate thermodynamics at the ice-shelf/ocean interface. This adds another level of complexity to Southern Ocean simulations, as ice shelves interact directly ...
Debernard, Jens B., England, Matthew H., Galton-Fenzi, Benjamin K., Hattermann, Tore, Hellmer, Hartmut H., Meissner, Katrin J., Naughten, Kaitlin A., Timmermann, Ralph   +7 more
core   +1 more source

NetCDF model output of the entire state of the surface layer, including simulated dFe dyes, of the circum-Antarctic [PDF]

, 2020
Dataset: Antarctic dFe model dyesFor a complete list of measurements, refer to the full dataset description in the supplemental file 'Dataset_description.pdf'.
Arrigo, Kevin R., Dinniman, Michael, Hofmann, Eileen E.   +2 more
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

High basal melting forming a channel at the grounding line of Ross Ice Shelf, Antarctica [PDF]

, 2016
Antarctica's ice shelves are thinning at an increasing rate, affecting their buttressing ability. Channels in the ice shelf base unevenly distribute melting, and their evolution provides insight into changing subglacial and oceanic conditions.
Catania, Ginny, Christianson, Knut, Corr, Hugh F. J., Fricker, Helen A., Marsh, Oliver J., Nicholls, Keith W,, Siegfried, Matthew R.   +6 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Fracture Mechanical Analysis of Cracks in Ice Shelves using the Finite Element Method and Configurational Forces [PDF]

, 2011
Ice shelves are important elements of the climate system and sensitive to climate changes. The disintegration of large Antarctic ice shelves is the focus of this fracture mechanical analysis. Ice is a complex material which, depending on the context, can
Gross, Dietmar, Humbert, Angelika, Müller, Ralf, Plate, Carolin   +3 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Variation in the seston C:N ratio of the Arctic Ocean and pan-Arctic shelves [PDF]

, 2014
Studying more than 3600 observations of particulate organic carbon (POC) and particulate organic nitrogen (PON), we evaluate the applicability of the classic Redfield C:N ratio (6.6) and the recently proposed Sterner ratio (8.3) for the Arctic Ocean and ...
Andersen, Tom, Bellerby, Richard G. J., Frigstad, Helene, Hessen, Dag O., Silyakova, Anna   +4 more
core   +1 more source