Results 71 to 80 of about 12,214 (254)

Comparing numerical ice-sheet model output with radio-echo sounding measurements in the Weddell Sea sector of West Antarctica

Annals of Glaciology, 2020
Numerical ice-sheet models are commonly matched to surface ice velocities from InSAR measurements by modifying basal drag, allowing the flow and form of the ice sheet to be simulated. Geophysical measurements of the bed are rarely used to examine if this
Hafeez Jeofry, Neil Ross, Martin J. Siegert   +2 more
doaj   +1 more source

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

Advanced Science, EarlyView.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai   +7 more
wiley   +1 more source

Ice stream motion facilitated by a shallow-deforming and accreting bed

Nature Communications, 2016
Ice streams are fundamental to ice sheet dynamics, but the mechanisms controlling their flow remain elusive. Here, the authors perform macro- and microscale analyses of mega-scale glacial lineations, which indicate a continuously accreting, shallow ...
Matteo Spagnolo, Emrys Phillips, Jan A. Piotrowski, Brice R. Rea, Chris D. Clark, Chris R. Stokes, Simon J. Carr, Jeremy C. Ely, Adriano Ribolini, Wojciech Wysota, Izabela Szuman   +10 more
doaj   +1 more source

Phocaeicola coprophilus‐Derived 6‐Methyluracil Attenuates Radiation‐Induced Intestinal Fibrosis by Suppressing the IDO1‐Kynurenine‐AHR Axis

Advanced Science, EarlyView.
IR‐induced dysbiosis depletes P. coprophilus and its metabolite 6‐methyluracil, leading to disinhibition of the IDO1‐Kyn‐AHR axis. This results in sustained fibroblast activation and collagen deposition, driving radiation induced intestinal fibrosis. ABSTRACT Therapeutic options for radiation‐induced intestinal fibrosis (RIF) remain limited. This study
Jiaxin Zhang, Zhen Wang, Shuang Li, Chao Luo, Han Li, Shengjie Ma, Pai Wang, Heshi Liu, Lijun Sun, Yue Yin, Weizhen Zhang, Quan Wang   +11 more
wiley   +1 more source

Competition Between Liquid‐Liquid Crystalline Phase Separation (LLCPS) and Liquid‐Liquid Phase Separation (LLPS) in Amyloid Fibril Colloidal Systems

Advanced Science, EarlyView.
This study shows that amyloid fibrils form nematic condensates via liquid–liquid crystalline phase separation (LLCPS). With increasing pH, this transition shifts toward disordered condensates formed through liquid–liquid phase separation (LLPS), in which birefringence with lack of a coherent nematic field symmetry originates from enthalpic fibril ...
Milad Radiom, Raffaele Mezzenga
wiley   +1 more source

Genese des Nordseeraumes im Quartär

Fennia: International Journal of Geography, 1974
In spite of alterations due to transgressions, Pleistocene forms are still discernible in the North Sea area. In this study, explanation of their genesis is based on a reconstruction of the ice‑sheds of different dimen­sions and the dynamic elements of ...
Heinrich Reinhard
doaj  

Multi-decadal evolution of Crary Ice Rise region, West Antarctica, amid modern ice-stream deceleration

Journal of Glaciology
The ongoing deceleration of Whillans Ice Stream, West Antarctica, provides an opportunity to investigate the co-evolution of ice-shelf pinning points and ice-stream flux variability.
Hannah Verboncoeur, Matthew Ross Siegfried, Nicholas Holschuh, Jeremy Paul Winberry, Duncan Byrne, Wilson Sauthoff, Tyler Clark Sutterley, Brooke Medley   +7 more
doaj   +1 more source

Groundwater dynamics beneath a marine ice sheet [PDF]

The Cryosphere
Sedimentary basins beneath many Antarctic ice streams host substantial volumes of groundwater, which can be exchanged with a “shallow” subglacial hydrological system of till and channelised water.
G. J. Cairns, G. P. Benham, G. P. Benham, I. J. Hewitt   +3 more
doaj   +1 more source

Adipocyte‐Derived Exosomal miR‐5099 Mitigates M1 Macrophage Polarization and Adipose Inflammation via c‐Met/NF‐κB Axis to Improve Metabolic Health

Advanced Science, EarlyView.
Celastrol upregulates adipocyte‐derived exosomal miR‐5099, suppressing the macrophage c‐Met/NF‐κB axis to mitigate pro‐inflammatory M1 polarization and adipose inflammation. These miR‐5099‐enriched exosomes also act as endocrine signals targeting the liver, muscle, and adipocytes to significantly enhance systemic insulin sensitivity.
Ping Tang, Lixin Tai, Hongxia Xu, Dongliang Zhu, Jiajia Li, Hao Feng, Jinghui Cui, Shuhai Lin, Li‐jun Di, Li Wang   +9 more
wiley   +1 more source

Microfluidic‐Driven Lipid Nanoparticles for Improved miRNA Delivery via Endo‐Lysosomal Trafficking Optimization

Advanced Science, EarlyView.
This study investigates the impact of various post‐processing methods (filtration, sonication, dialysis, and heating) on lipid nanoparticles produced using microfluidics. The nanoparticles are designed for efficient delivery of miRNA into cells. The work highlights how processing conditions influence nanoparticle stability and quality, providing ...
Alicja Kosik‐Kozioł, Michał Pruchniewski, Daniel Rybak, Piotr Jenczyk, Karolina Zakrzewska, Magdalena Bartolewska, Sławomir Błoński, Paweł Nakielski, Filippo Pierini   +8 more
wiley   +1 more source