Results 81 to 90 of about 856,577 (241)

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

Greenland Ice Sheet and rising sea level in a worst-case climate change scenario [PDF]

, 2004
P(論文)Models that simulate sheet flow in the Greenland Ice Sheet balance forces at gridpoints in the map plan, which allows only a slow response to changes in climate forcing. A holistic approach to modeling allows a rapid response that takes place in ice
Terry Hughes
core   +1 more source

An Unbiased Geometry‐Resolved Membrane Platform for Proteome‐Scale Discovery of Membrane Curvature Sensors

Advanced Science, EarlyView.
A novel geometry‐resolved membrane platform provides a seamlessly integrated pipeline for studying curvature‐sensing proteins. By linking shotgun proteomics with quantitative imaging, this approach enables both the unbiased discovery and rigorous validation of novel sensors across the entire curvature range—positive, negative, and zero.
Takumi Komikawa, Rikuto Kawakami, Kunanon Chattrairat, Tatsuya Niwa, Taiga Ajiri, Takao Yasui, Masayoshi Tanaka   +6 more
wiley   +1 more source

A temperate former West Antarctic ice sheet suggested by an extensive zone of bed channels [PDF]

, 2014
We present radio-echo sounding data and satellite imagery, revealing a series of ancient large sub-parallel subglacial channels preserved in the region between the Möller and Foundation Ice Streams, West Antarctica.
Martin J. Siegert, Tom A. Jordan, Rippin, David M., Jordan, Tom A., Ross, N, Siegert, MJ, Corr, HFJ, Siegert, Martin J., Rippin, DM, Le Brocq, Anne, Hugh F.J. Corr, Jordan, TA, Kathryn C. Rose, Le Brocq, Anne M., Rose, Kathryn C., Bingham, RG, Le Brocq, AM, Anne M. Le Brocq, Ross, Neil, Fausto Ferraccioli, Rose, KC, Ferraccioli, F, Ferraccioli, Fausto, Corr, Hugh F.J., Robert G. Bingham, Neil Ross, David M. Rippin, Bingham, Robert G., K.C. Rose (9005840), et al. (281964)   +29 more
core   +1 more source

Estimation of ice fabric within Whillans Ice Stream using polarimetric phase-sensitive radar sounding

Annals of Glaciology, 2020
Here we use polarimetric measurements from an Autonomous phase-sensitive Radio-Echo Sounder (ApRES) to investigate ice fabric within Whillans Ice Stream, West Antarctica.
Thomas M. Jordan, Dustin M. Schroeder, Cooper W. Elsworth, Matthew R. Siegfried   +3 more
doaj   +1 more source

Sex‐ and Time‐Resolved Physiological and Gut Ecosystem Responses to a Food‐Grade Microbiome‐Targeted Intervention in Collegiate Endurance Athletes

Advanced Science, EarlyView.
In collegiate endurance athletes, a 6‐week randomized CPYE intervention yielded time‐ and sex‐dependent shifts in field‐based cardiorespiratory, metabolic, and redox indices, accompanied by changes in gut multi‐omics profiles. An exploratory extension during intensified training generates hypotheses warranting future validation.
Meng Zhang, Le Ge, Kaiyang Liu, Yanrong Liu, Guolin Zhao, Lai‐Yu Kwok, Zheng Sun, Zhihong Sun, Wenyi Zhang   +8 more
wiley   +1 more source

Self‐Sustaining Sensing Systems: Integration Strategies and Signal–Power Matching in Energy‐Harvesting Electronics

Advanced Science, EarlyView.
Energy‐harvesting‐integrated sensors couple ambient energy conversion with sensing, processing, and wireless communication. This review organizes recent progress through integration architectures and operating principles, revisiting co‐packaged, monolithic, and co‐functional designs together with always‐on, event‐driven, and multi‐modal sensing modes ...
Taehyun Park, Ki‐Yoon Park, Yeonho Choi, Dong‐Myeong Shin, Hong‐Joon Yoon, Hocheon Yoo   +5 more
wiley   +1 more source

Tributaries to West Antarctic ice Streams: Characteristics Deduced from Numerical Modelling of Ice Flow [PDF]

, 2000
A network of relatively fast-flowing tributaries in the catchment basins of the West Antarctic ice streams transport ice from the inland reservoir to the heads of the ice streams.
Morse, David L., Joughin, Ian R., Bindschadler, R. A., Hulbe, Christina L., David L. Morse, Robert A. Bindschadler, Ian R. Joughin, Christina L. Hulbe   +7 more
core   +1 more source

Functional MXene Inks for Printed Electronics: Chemistry, Rheology, and Devices

Advanced Science, EarlyView.
Functional MXene inks are emerging as building blocks for MXetronics, connecting MXene synthesis, surface functionalization, ink formulation, and advanced printing with device‐level applications. This review maps how composition, stability, rheology, and processability govern printed structures and enable high‐performance sensors, energy‐storage ...
Shahzaib Ali, Faisal Shahzad, Hamza Hussain, Muhammad Abbas, Dae‐Hyun Cho, Doyoung Byun, Hassan A. Arafat   +6 more
wiley   +1 more source

Oral Recombinant Human Collagen III Protects Gastric Mucosa via G‐Quadruplex‐Mediated Activation of the Pla2g4a‐Prostaglandin Axis

Advanced Science, EarlyView.
Orally administered recombinant human type III collagen protects the gastric mucosa from ethanol‐induced injury by coordinating redox homeostasis, epithelial barrier repair, and arachidonic acid–prostaglandin metabolism. Gastric digestion releases the pentapeptide GPAEF, which interacts with the Pla2g4a promoter G‐quadruplex in a structure‐dependent ...
Xinyue Lan, Qiu Dai, Yanhui Wang, Jiaxuan Gu, Chengyun Wang, Weicheng Xu, Xinru Gao, Jiageng Cheng, Wentao Geng, Xiaowen Wu, Haihang Li, Xiaoyun He, Shengwei Fu, Longjiao Zhu, Wentao Xu   +14 more
wiley   +1 more source