Results 71 to 80 of about 2,495,019 (275)

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons

PLoS Genetics, 2017
Sjögren’s syndrome (SS) is a common, autoimmune exocrinopathy distinguished by keratoconjunctivitis sicca and xerostomia. Patients frequently develop serious complications including lymphoma, pulmonary dysfunction, neuropathy, vasculitis, and ...
He Li, T. R. Reksten, J. Ice, J. Kelly, I. Adrianto, A. Rasmussen, Shaofeng Wang, Bo He, K. Grundahl, S. Glenn, C. Miceli-Richard, S. Bowman, S. Lester, P. Eriksson, M. Eloranta, J. Brun, Lasse G. Gøransson, E. Harboe, J. Guthridge, K. Kaufman, M. Kvarnström, D. C. Cunninghame Graham, Ketan J. Patel, A. Adler, A. Farris, Michael T. Brennan, J. Chodosh, R. Gopalakrishnan, Michael H. Weisman, S. Venuturupalli, D. Wallace, K. Hefner, G. Houston, Andrew J. W. Huang, P. Hughes, D. Lewis, L. Radfar, Evan S. Vista, Contessa E. Edgar, Michael D. Rohrer, D. Stone, T. Vyse, J. Harley, P. Gaffney, Judith A. James, Sean Turner, I. Alevizos, J. Anaya, N. Rhodus, B. Segal, C. Montgomery, R. Scofield, S. Kovats, X. Mariette, L. Rönnblom, T. Witte, M. Rischmueller, M. Wahren-Herlenius, R. Omdal, R. Jonsson, W. Ng, G. Nordmark, C. Lessard, K. Sivils   +63 more
semanticscholar   +1 more source

Airborne radar evidence for tributary flow switching in Institute Ice Stream, West Antarctica: implications for ice sheet configuration and dynamics [PDF]

, 2015
Despite the importance of ice streaming to the evaluation of West Antarctic Ice Sheet (WAIS) stability we know little about mid- to long-term dynamic changes within the Institute Ice Stream (IIS) catchment.
Martin J. Siegert, Hugh F. J. Corr, Corr, Hugh, Bingham, RG, Woodward, John, Ross, Neil, Ross, N, Dunning, SA, Corr, Hugh F.J., Winter, K, Siegert, MJ, Robert G. Bingham, Winter, Kate, Dunning, Stuart, John Woodward, Neil Ross, Siegert, Martin, Corr, HFJ, Kate Winter, Dunning, Stuart A., Siegert, Martin J., Stuart A. Dunning, Bingham, Robert G., Woodward, J   +23 more
core   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

A study of the dynamics of the British Ice Sheet during Marine Isotope Stages 2 and 3, focusing on Heinrich Events 2 and 4 and their relationship to the North Atlantic glaciological and climatological conditions [PDF]

, 2007
A high-resolution investigation into the stratigraphy of core MD95-2006 from the Barra fan, NW Scottish continental slope has been carried out. The study focuses on key palaeoceanographic proxies (percentage Neogloboquadrina pachyderma (s), planktonic ...
Leigh, Sasha Naomi Bharier
core   +2 more sources

Pre-late Weichselian podzol soil, permafrost features and lithostratigraphy at Penttilänkangas, western Finland [PDF]

Bulletin of the Geological Society of Finland, 2009
The ridge-shaped Penttilänkangas accumulation in western Finland is glaciofluvial in origin: probably an ice-marginal subaquatic fan, reworked and covered with younger deep water, littoral, eolian and glacial sediments.
R. Pitkäranta
doaj   +1 more source

Microstructure Reconstruction in Battery Electrodes Using Machine Learning Based on Low‐Voltage Focused Ion Beam–Scanning Electron Microscopy Tomography Images

Advanced Engineering Materials, EarlyView.
Low‐voltage FIB‐SEM tomography combined with a image preprocessing pipeline improves phase contrast and enables reliable machine‐learning segmentation of conductive networks in lithium‐ion battery electrodes. Structural descriptors are extracted from segmented images, done semimanually and automated, and compared.
Lisa Beran, Vincent Nebel, Dominik Perius, Kshitij Kumar, Yannis Heim, Laura Bies, Tobias Kraus   +6 more
wiley   +1 more source

The Aerodynamic Effects of Runback Ice [PDF]

, 2013
The objectives of this PhD were to investigate the aerodynamic performance effects due to runback ice accretion with particular interest on the EASA 45 minute hold case in icing conditions. The sponsors, Airbus and Cranfield University collaboratively
Parmar, Krishan
core   +5 more sources

Morphology, Transport, and Dynamics of Protein Adsorption in Open‐Cell Metal Foam

Advanced Engineering Materials, EarlyView.
Stainless steel (SS) open‐cell foams are shown to adsorb more protein per unit area than previously reported 316L SS and chromium oxide surfaces under static and flow conditions. An integrated approach combining 3D pore imaging, flow simulation, and protein adsorption experiments characterizes the foam’s performance.
Chinmaya Prerana Inguva, Joseph Lavoie, Afsaneh Rabiei   +2 more
wiley   +1 more source