Results 181 to 190 of about 4,109,816 (309)

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Mass balance of the Greenland and Antarctic ice sheets from the 1970s to 2023. [PDF]

Sci Data
Otosaka IN, Shepherd A, Amory C, Horwath M, Ivins ER, King MD, Nowicki S, Payne AJ, Rignot E, Sørensen LS, Schlegel NJ, Simon KM, Smith BE, Sutterley TC, van den Broeke MR, Velicogna I, A G, Agosta C, Ditmar P, Döhne T, Engdahl ME, Fettweis X, Forsberg R, Gardner AS, Gilbert L, Goelzer H, Gourmelen N, Groh A, Hansen N, Harig C, Helm V, Khan SA, Kittel C, Langen PL, Larsen M, Loomis BD, McMillan M, Medley B, Melini D, Mottram RH, Muir A, Nilsson J, Noël B, Pattle ME, Roca I Aparici M, Sasgen I, Save HV, Scheuchl B, Schrama EJO, Schröder L, Seo KW, Simonsen SB, Slater T, Spada G, Vishwakarma BD, Wever N, Wiese DN, Wouters B.   +57 more
europepmc   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Formation of nanoscale vapour films governing thermal resistance in amorphous ice. [PDF]

Commun Chem
Liu Y, Eklund T, Karina A, Hövelmann S, Bauer RPC, You S, Goy C, Striker NN, Gierke A, Hess K, Schlage K, Bocklage L, Ardana Lamas F, Wang H, Jiang Y, Uemara Y, Milne C, Kim KH, Murphy B, Lehmkühler F, Zalden P, Amann-Winkel K.   +21 more
europepmc   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Modelling Future Evolution of the Antarctic Ice Sheet With Explainable Machine Learning. [PDF]

J R Soc N Z
Maddigan P, Nguyen BH, Siew PYF, Xue B, Golledge N, Zhang M.   +5 more
europepmc   +1 more source

Iron‐Mediated Release of Aged Dissolved Organic Carbon From Waterlogged Peatland Under Warming

Advanced Science, EarlyView.
This study conducts a five‐year in situ warming experiment in high‐altitude peatlands to examine dissolved organic carbon (DOC) release. The study shows that warming promotes the release of plant‐derived modern DOC in drained peatlands, but amplifies aquatic export of century‐old DOC from waterlogged peatlands via Fe‐mediated DOC mobilization—a ...
Guohua Dai, Zhiying Yang, Zongguang Liu, Wanjia Hu, Lixiao Ma, Enze Kang, Wanqing Luo, Yunpeng Zhao, Chengzhu Liu, Juan Jia, Ting Liu, Chen He, Quan Shi, Jianliang Liu, Yongheng Gao, Huai Chen, Hailong Zhang, Meixun Zhao, Xiaojuan Feng   +18 more
wiley   +1 more source

Histology and morphometry of the skin of the Korean ice goby Leucopsarion petersii (Gobiiformes, Gobiidae), in relation to its ecology and habitat. [PDF]

Appl Microsc
Sung MS, Kim HT.
europepmc   +1 more source

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Modeling of the electrostatic field generated by horizontal current sources in a sea-ice-covered four-layer medium. [PDF]

Sci Rep
Chen X, Sun Z, Jiang C, Zhu K, Li M, Jiang R, Yang W, Yan K, Du Y.   +8 more
europepmc   +1 more source