Results 191 to 200 of about 270,103 (305)

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Entrained debris records regrowth of the Greenland Ice Sheet after the last interglacial. [PDF]

Nat Geosci
Holschuh N, Christianson K, Dienstfrey W, Hills B, Hoffman AO, Paden J, Winter K, Zuraw R.   +7 more
europepmc   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Field data on sea ice restoration by artificial flooding in subarctic Canada. [PDF]

Data Brief
Owen CC, Afzali S, Schellingerhout W, Meijeraan T, Ypma F.   +4 more
europepmc   +1 more source

Airborne electromagnetic measurements of sea ice thickness: methods and applications [PDF]

, 2007
Göbell, Sibylle, Haas, Christian, Hendricks, Stefan, Martin, Torge, Pfaffling, A., von Saldern, C.   +5 more
core  

How Neuromorphic Microstructures Control In Vitro Early‐Stage Neuronal Outgrowth

Advanced Science, EarlyView.
Biomimetic approach to neuronal interaction with neuromorphic microstructures. ABSTRACT Neuromorphic biomaterials represent a novel class of materials designed to replicate the architecture and functionality of neuronal structures, offering new opportunities in tissue engineering and bioelectronics.
Claudia Latte Bovio, Esther Matamoros, Valentina Mollo, Anna Mariano, Valeria Criscuolo, Francesca Santoro   +5 more
wiley   +1 more source

Probing the structure of D₂O ice layers on ALD-grown ZrO₂, Al₂O₃ and TiO₂ thin films by sum frequency generation (SFG) spectroscopy.

Faraday Discuss
Li X, Gross S, Haunold T, Jang MH, Zukalova M, Jindra M, Olszówka JE, Lei Y, Vajda Š, Rupprechter G.   +9 more
europepmc   +1 more source

Ice sublimation transfer of vertically aligned carbon nanotubes for residue-free and structure-preserving integration. [PDF]

Nat Commun
Han H, Hwang K, Jo E, Koh D, Heo B, Kim J.   +5 more
europepmc   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Effect of water quality on ice hardness and skate-to-ice friction in ice rinks. [PDF]

Sports Eng
Hutchins RHS, Wang J, Impellizzeri S.
europepmc   +1 more source