Results 41 to 50 of about 75,003 (265)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Coherent radar ice thickness measurements over the Greenland ice sheet [PDF]

Journal of Geophysical Research: Atmospheres, 2001
We developed two 150‐MHz coherent radar depth sounders for ice thickness measurements over the Greenland ice sheet. We developed one of these using connectorized components and the other using radio frequency integrated circuits (RFICs). Both systems are designed to use pulse compression techniques and coherent integration to obtain the high ...
Gogineni, Sivaprasad, Tammana, Dilip, Braaten, David A., Leuschen, Carl J., Legarsky, Justin, Kanagaratnam, Pannirselvam, Stiles, James Marion, Allen, Christopher Thomas, Jezek, Kenneth C., Akins, Torry L.   +9 more
openaire   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Uncertainty Assessment of Ice Discharge Using GPR-Derived Ice Thickness from Gourdon Glacier, Antarctic Peninsula

Geosciences, 2019
Ice cliffs within a glacier represent a challenge for the continuity equations used in many glacier models by interrupting the validity of input parameters. In the case of Gourdon Glacier on James Ross Island, Antarctica, a ∼300−500 m
Stefan Lippl, Norbert Blindow, Johannes J. Fürst, Sebastián Marinsek, Thorsten C. Seehaus, Matthias H. Braun   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Radar measurements of ice sheet thickness of outlet glaciers in Greenland [PDF]

IEEE International Geoscience and Remote Sensing Symposium, 2003
We have conducted airborne measurements over the Greenland ice sheet from the NASA P-3B aircraft using a 150-MHz coherent radar depth sounder to obtain extensive ice sheet thickness measurements. Simultaneous measurements of ice sheet elevation were also made using a laser altimeter.
David Braaten, Sivaprasad Gogineni
openaire   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Modeling the thickness of perennial ice covers on stratified lakes of the Taylor Valley, Antarctica

Journal of Glaciology, 2016
A 1-D ice cover model was developed to predict and constrain drivers of long-term ice thickness trends in chemically stratified lakes of Taylor Valley, Antarctica.
M. K. OBRYK, P. T. DORAN, J. A. HICKS, C. P. McKAY, J. C. PRISCU   +4 more
doaj   +1 more source

Estimation of sea ice parameters from sea ice model with assimilated ice concentration and SST [PDF]

The Cryosphere, 2018
A multi-category numerical sea ice model CICE was used along with data assimilation to derive sea ice parameters in the region of Baffin Bay and Labrador Sea.
S. Prasad, I. Zakharov, P. McGuire, P. McGuire, D. Power, M. Richard   +5 more
doaj   +1 more source