Results 51 to 60 of about 4,109,816 (309)

Airborne radar ice thickness measurements in Antarctica 1994-2007

, 2023
In these datasets we publish ice thickness data collected by ice-penetrating radar measurements of the Alfred Wegener Institute between the years 1994 and 2007.
Miller, Heinrich, Helm, Veit, Franke, Steven, Steinhage, Daniel, Eisen, Olaf   +4 more
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Coherent radar ice thickness measurements over the Greenland ice sheet [PDF]

Journal of Geophysical Research: Atmospheres, 2001
We developed two 150‐MHz coherent radar depth sounders for ice thickness measurements over the Greenland ice sheet. We developed one of these using connectorized components and the other using radio frequency integrated circuits (RFICs). Both systems are designed to use pulse compression techniques and coherent integration to obtain the high ...
Gogineni, Sivaprasad, Tammana, Dilip, Braaten, David A., Leuschen, Carl J., Legarsky, Justin, Kanagaratnam, Pannirselvam, Stiles, James Marion, Allen, Christopher Thomas, Jezek, Kenneth C., Akins, Torry L.   +9 more
openaire   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Uncertainty Assessment of Ice Discharge Using GPR-Derived Ice Thickness from Gourdon Glacier, Antarctic Peninsula

Geosciences, 2019
Ice cliffs within a glacier represent a challenge for the continuity equations used in many glacier models by interrupting the validity of input parameters. In the case of Gourdon Glacier on James Ross Island, Antarctica, a ∼300−500 m
Stefan Lippl, Norbert Blindow, Johannes J. Fürst, Sebastián Marinsek, Thorsten C. Seehaus, Matthias H. Braun   +5 more
doaj   +1 more source

Near-real-time Arctic sea ice thickness and volume from CryoSat-2 [PDF]

The Cryosphere, 2016
Timely observations of sea ice thickness help us to understand the Arctic climate, and have the potential to support seasonal forecasts and operational activities in the polar regions.
R. L. Tilling, A. Ridout, A. Shepherd
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Measuring sea ice through thick and thin [PDF]

Science, 2014
Climate Change Sea ice in the Arctic's Fram Straight is only half as thick as it was a decade ago, Renner and colleagues report. Measuring ice both at the surface and from the air with an instrument towed below a helicopter, they found that the ice in that region thinned by more than 50% between 2003 and 2012.
openaire   +1 more source