Results 51 to 60 of about 1,501,662 (301)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Лëд и снег, 2015 The article provides phenomenological and experimental arguments that ice sheet surface fluctuation in Antarctica is mediated by ice velocity and subglacial water flow.
V. M. Kotlyakov +4 more
doaj +1 more source
The response of a floating ice sheet to an accelerating line load [PDF]
, 2003 The two-dimensional response of a thin, floating sheet of ice to a line load that accelerates from rest at $t = 0$ to a uniform velocity V for $t \geq T$ is determined through an integral-transform solution of the linearized equations of motion.
Miles, J., Sneyd, Alfred D.
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Journal of Marine Science and Engineering, 2022 Ice core drilling with air reverse circulation is a promising technology that uses high-speed airflow to transport the ice core from the bottom of the hole along the central passage of the drill pipe to the surface.
Mengke Wang +5 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
The distribution of basal motion beneath a High Arctic polythermal glacier [PDF]
, 2003 The longitudinal pattern of surface velocity of a large, predominantly colds polythermal glacier (John Evans Glacier, Ellesmere Island, Canada) was measured over summer and winter periods.
Nienow, Peter W. +12 more
core +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Ice flow velocity of the Nioghalvfjerdsfjorden Glacier and Zachariæ Isstrøm, Northeast Greenland, in the 1960s from Historical Satellite Imagery [PDF]
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information SciencesThe Northeast Greenland Ice Stream (NEGIS) is experiencing sustained accelerated mass loss due to the combined effects of atmospheric and ocean warming.
L. Dai +7 more
doaj +1 more source
The Statistical Properties of Sea Ice Velocity Fields
Journal of Climate, 2017 By arguing that the surface pressure field over the Arctic Ocean can be treated as an isotropic, stationary, homogeneous, Gaussian random field, Thorndike estimated a number of covariance functions from two years of data (1979 and 1980). Given the active interest in changes of general circulation quantities and indices in the polar regions during the ...
Agarwal, Sahil, Wettlaufer, John S.
openaire +2 more sources