Results 51 to 60 of about 302,667 (302)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Ice flow velocity of the Nioghalvfjerdsfjorden Glacier and Zachariæ Isstrøm, Northeast Greenland, in the 1960s from Historical Satellite Imagery [PDF]

open access: yesThe International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences
The Northeast Greenland Ice Stream (NEGIS) is experiencing sustained accelerated mass loss due to the combined effects of atmospheric and ocean warming.
L. Dai   +7 more
doaj   +1 more source

Short-term variability in Greenland Ice Sheet motion forced by time-varying meltwater inputs: implications for the relationship between subglacial drainage system behavior and ice velocity. [PDF]

open access: yes, 2012
High resolution measurements of ice motion along a -120 km transect in a land-terminating section of the GrIS reveal short-term velocity variations (
Anderson   +56 more
core   +4 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Relationship of surface elevation changes of the Antarctic ice sheet with ice movement and subglacial water flow

open access: yesЛëд и снег, 2015
The article provides phenomenological and experimental arguments that ice sheet surface fluctuation in Antarctica is mediated by ice velocity and subglacial water flow.
V. M. Kotlyakov   +4 more
doaj   +1 more source

Cirrus parameterisation and the role of ice nuclei. [PDF]

open access: yes, 2005
A parametrization of cirrus clouds formed by homogeneous nucleation is improved so that it can be used more easily in general-circulation models (GCMs) and climate models.
MacKenzie, Rob, Ren, C.
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Velocity increases at Cook Glacier, East Antarctica, linked to ice shelf loss and a subglacial flood event [PDF]

open access: yesThe Cryosphere, 2018
Cook Glacier drains a large proportion of the Wilkes Subglacial Basin in East Antarctica, a region thought to be vulnerable to marine ice sheet instability and with potential to make a significant contribution to sea level.
B. W. J. Miles   +2 more
doaj   +1 more source

Radioglaciological studies on Hurd Peninsula glaciers, Livingston Island, Antarctica [PDF]

open access: yes, 2009
We present the results of several radio-echo sounding surveys carried out on Johnsons and Hurd Glaciers, Livingston Island, Antarctica, between the 1999/2000 and 2004/05 austral summer campaigns, which included both radar profiling and common-midpoint ...
Ahlstrom, L.P.   +6 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

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