Results 61 to 70 of about 1,501,662 (301)

Ice-flow velocity from Jacobshavn, Kangerdlugssuaq and Petermann Glacier, Greenland

, 2018
Ice-flow velocity fields produced from optical feature tracking of Landsat data, using ImGRAFT toolbox. Data are provided in point NetCDF format along with a corresponding JPEG, a data timeline and example data structure are also provided. See attached
Grinsted, Aslak, Karlsson, Nanna Bjørnholt, Alexandra Messerli (7883156), Aslak Grinsted (7698518), Nanna B Karlsson (7883159), Messerli, Alexandra   +5 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

balance velocities of the Greenland Ice Sheet [PDF]

Geophysical Research Letters, 1997
We present a map of balance velocities for the Greenland ice sheet. The resolution of the underlying DEM, which was derived primarily from radar altimetery data, yields far greater detail than earlier balance velocity estimates for Greenland. The velocity contours reveal in striking detail the location of an ice stream in northeastern Greenland, which ...
Ian Joughin, Mark Fahnestock, Simon Ekholm, Ron Kwok   +3 more
openaire   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Velocity increases at Cook Glacier, East Antarctica, linked to ice shelf loss and a subglacial flood event [PDF]

The Cryosphere, 2018
Cook Glacier drains a large proportion of the Wilkes Subglacial Basin in East Antarctica, a region thought to be vulnerable to marine ice sheet instability and with potential to make a significant contribution to sea level.
B. W. J. Miles, C. R. Stokes, S. S. R. Jamieson   +2 more
doaj   +1 more source

Ice-flow velocity, Petermann Glacier, Greenland

, 2018
Ice-flow velocity fields produced from optical feature tracking of Landsat data, using ImGRAFT toolbox. Data are provided in point NetCDF format along with a corresponding JPEG, a data timeline and example data structure are also provided. See attached
Grinsted, Aslak, Karlsson, Nanna Bjørnholt, Alexandra Messerli (7883156), Aslak Grinsted (7698518), Nanna B Karlsson (7883159), Messerli, Alexandra   +5 more
core   +1 more source

Improving the spatial distribution of modeled Arctic sea ice thickness [PDF]

, 2005
The spatial distribution of ice thickness/draft in the Arctic Ocean is examined using a sea ice model. A comparison of model predictions with submarine observations of sea ice draft made during cruises between 1987 and 1997 reveals that the model has the
Laxon, SW, Miller, PA, Feltham, DL, Laxon, S. W., Feltham, D. L., Miller, P. A.   +5 more
core   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Ice-flow velocity, Jakobshavn Glacier, Greenland

, 2018
Ice-flow velocity fields produced from optical feature tracking of Landsat data, using ImGRAFT toolbox. Data are provided in point NetCDF format along with a corresponding JPEG, a data timeline and example data structure are also provided. See attached
Grinsted, Aslak, Karlsson, Nanna Bjørnholt, Alexandra Messerli (7883156), Aslak Grinsted (7698518), Nanna B Karlsson (7883159), Messerli, Alexandra   +5 more
core   +1 more source

An ice-sheet scale comparison of eskers with modelled subglacial drainage routes [PDF]

, 2015
Eskers record the signature of channelised meltwater drainage during deglaciation providing vital information on the nature and evolution of subglacial drainage.
Stokes, C.R., C.D. Clark (630927), Storrar, RD, Clark, CD, Tarasov, L, Stokes, Chris R., Hillier, J.K., Clark, C.D., Livingstone, SJ, Clark, Chris D., C.R. Stokes (630946), Tarasov, L., Livingstone, S.J., Stephen J. Livingstone (3691018), Tarasov, Lev, Livingstone, Stephen J., John Hillier (1254873), Storrar, Robert D., R. Storrar (630947), Hillier, JK, Hillier, John K., L. Tarasov (7191965), Storrar, R.D., Stokes, CR   +23 more
core   +1 more source