Results 71 to 80 of about 302,667 (302)

The shallow shelf approximation as a "sliding law" in a thermomechanically coupled ice sheet model

, 2008
The shallow shelf approximation is a better ``sliding law'' for ice sheet modeling than those sliding laws in which basal velocity is a function of driving stress.
Aschwanden, Balay, Blatter, Bueler, Bueler, Clarke, Ed Bueler, Fowler, Fowler, Greve, Greve, Greve, Greve, Hindmarsh, Hindmarsh, Howat, Hulbe, Hutter, Huybrechts, Huybrechts, Jed Brown, Jenssen, Johnson, Joughin, Joughin, Joughin, Joughin, MacAyeal, MacAyeal, Mahaffy, Marshall, Marshall, Marshall, Morland, Morland, Morton, Paterson, Paterson, Pattyn, Pattyn, Payne, Pollard, Raymond, Ritz, Ritz, Saad, Saito, Saito, Saito, Schoof, Schoof, Schoof, Schoof, Shepherd, Tarasov, Truffer, Truffer, Tulaczyk, Tulaczyk, Vaughan, Weis, Wesseling, Zwally, Zwinger   +63 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Molecular-dynamics simulation of clustering processes in sea-ice floes

, 2011
In seasonally ice-covered seas and along the margins of perennial ice pack, i.e. in regions with medium ice concentrations, the ice cover typically consists of separate floes interacting with each other by inelastic collisions.
Herman, Agnieszka
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Sixty years of ice form and flow at Camp Century, Greenland

Journal of Glaciology, 2023
The magnitude and azimuth of horizontal ice flow at Camp Century, Greenland have been measured several times since 1963. Here, we provide a further two independent measurements over the 2017–21 period.
William Colgan, Jakob Jakobsen, Anne Solgaard, Anja Løkkegaard, Jakob Abermann, Shfaqat A. Khan, Beata Csatho, Joseph A. MacGregor, Robert S. Fausto, Nanna Karlsson, Allan Ø. Pedersen, Signe B. Andersen, John Sonntag, Christine S. Hvidberg, Andreas P. Ahlstrøm   +14 more
doaj   +1 more source

Measurements of ice-ice friction coefficients at low sliding velocities

Journal of the Japanese Society of Snow and Ice, 2003
非回転式の摩擦測定器を製作し,低温室（-10℃）で滑り速度10-7m/s～10-3m/sおよび垂直応力123,245,368kPaにおける氷・氷および氷・他物質（ガラス,花崗岩）の摩擦測定を行った.氷・氷摩擦係数は,速度を10-4m/sから10-7m/sまで減少させるにつれて,0.1から1まで増加した.一方,氷・ガラス摩擦では速度10-3m/sから10-5m/sまで減少させるにつれて,0.04から0.02まで減少した.この速度領域における氷・氷摩擦係数が,低速度ほど増加する結果は,これまでの伝統的な凝着理論,すなわち摩擦面の氷の塑性流動だけでは説明できない.氷・花崗岩の摩擦係数は,速度を10-3m/sから10-6m/sまで減少させるにつれて,はじめ増加した後に減少した.氷 ...
Shigeki KANAZAWA, Masahiko ARAKAWA, Norikazu MAENO   +2 more
openaire   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

The Statistical Properties of Sea Ice Velocity Fields

Journal of Climate, 2017
By arguing that the surface pressure field over the Arctic Ocean can be treated as an isotropic, stationary, homogeneous, Gaussian random field, Thorndike estimated a number of covariance functions from two years of data (1979 and 1980). Given the active interest in changes of general circulation quantities and indices in the polar regions during the ...
Agarwal, Sahil, Wettlaufer, John S.
openaire   +2 more sources