Results 71 to 80 of about 69,716 (313)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Decadal GPS-derived ice surface velocity along the transect from Zhongshan Station to and around Dome Argus, East Antarctica, 2005–16

Annals of Glaciology, 2018
Using repeat GPS measurements during 2005–16, we calculated and updated two-dimensional high-resolution decadal ice surface velocity estimates along the traverse route from Zhongshan Station to and around Dome Argus, East Antarctica.
Yang Yuande, Ke Hao, Wang Zemin, Li Fei, Ding Minghu, Sun Bo, Jin Bo, Wang Lianzhong, Ai Songtao   +8 more
doaj   +1 more source

Ice Surface Velocity in the Eastern Arctic from Past Spaceborne Satellite SAR data

, 2021
Nearly complete mosaics of winter ice surface velocities for the 1990's over the Eastern Arctic (Novaya Zemlya, Franz-Josef-Land, Severnaya Zemlya and Svalbard) were compiled based on historical SAR data.
Kääb, Andreas, Wiesmann, Andreas, Paul, Frank, Strozzi, Tazio, Schellenberger, Thomas   +4 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

An assessment of key model parametric uncertainties in projections of Greenland Ice Sheet behavior [PDF]

, 2012
Lack of knowledge about the values of ice sheet model input parameters introduces substantial uncertainty into projections of Greenland Ice Sheet contributions to future sea level rise.
Stone, Emma J., N. Kirchner, K. Keller, Keller, K., Greve, Ralf, Applegate, P. J., Greve, R., R. Greve, Keller, Klaus, Kirchner, N., Applegate, Patrick J.,, Applegate, Patrick J., Kirchner, Nina, Stone, EJ, Kirchner, Nina,, E. J. Stone, Stone, E. J., P. J. Applegate   +17 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Sixty years of ice form and flow at Camp Century, Greenland

Journal of Glaciology, 2023
The magnitude and azimuth of horizontal ice flow at Camp Century, Greenland have been measured several times since 1963. Here, we provide a further two independent measurements over the 2017–21 period.
William Colgan, Jakob Jakobsen, Anne Solgaard, Anja Løkkegaard, Jakob Abermann, Shfaqat A. Khan, Beata Csatho, Joseph A. MacGregor, Robert S. Fausto, Nanna Karlsson, Allan Ø. Pedersen, Signe B. Andersen, John Sonntag, Christine S. Hvidberg, Andreas P. Ahlstrøm   +14 more
doaj   +1 more source

Measurements of ice-ice friction coefficients at low sliding velocities

Journal of the Japanese Society of Snow and Ice, 2003
非回転式の摩擦測定器を製作し,低温室（-10℃）で滑り速度10-7m/s～10-3m/sおよび垂直応力123,245,368kPaにおける氷・氷および氷・他物質（ガラス,花崗岩）の摩擦測定を行った.氷・氷摩擦係数は,速度を10-4m/sから10-7m/sまで減少させるにつれて,0.1から1まで増加した.一方,氷・ガラス摩擦では速度10-3m/sから10-5m/sまで減少させるにつれて,0.04から0.02まで減少した.この速度領域における氷・氷摩擦係数が,低速度ほど増加する結果は,これまでの伝統的な凝着理論,すなわち摩擦面の氷の塑性流動だけでは説明できない.氷・花崗岩の摩擦係数は,速度を10-3m/sから10-6m/sまで減少させるにつれて,はじめ増加した後に減少した.氷 ...
KANAZAWA, Shigeki, ARAKAWA, Masahiko, MAENO, Norikazu   +2 more
openaire   +2 more sources

Impact of Variable Atmospheric and Oceanic Form Drag on Simulations of Arctic Sea Ice [PDF]

, 2014
Over Arctic sea ice, pressure ridges and floe and melt pond edges all introduce discrete obstructions to the flow of air or water past the ice and are a source of form drag.
Laxon, Seymour W., Farell, Sinead, Bacon, Sheldon, Schroeder, David, Kurtz, Nathan, Flocco, Daniela, Feltham, Daniel L., Tsamados, Michel, Farrell, Sinead L., Flocco, Dani, Feltham, Danny, Laxon, Seymour   +11 more
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source