Results 71 to 80 of about 302,803 (284)
Sixty years of ice form and flow at Camp Century, Greenland
Journal of Glaciology, 2023 The magnitude and azimuth of horizontal ice flow at Camp Century, Greenland have been measured several times since 1963. Here, we provide a further two independent measurements over the 2017–21 period.
William Colgan +14 more
doaj +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Measurements of ice-ice friction coefficients at low sliding velocities
Journal of the Japanese Society of Snow and Ice, 2003 非回転式の摩擦測定器を製作し,低温室（-10℃）で滑り速度10-7m/s～10-3m/sおよび垂直応力123,245,368kPaにおける氷・氷および氷・他物質（ガラス,花崗岩）の摩擦測定を行った.氷・氷摩擦係数は,速度を10-4m/sから10-7m/sまで減少させるにつれて,0.1から1まで増加した.一方,氷・ガラス摩擦では速度10-3m/sから10-5m/sまで減少させるにつれて,0.04から0.02まで減少した.この速度領域における氷・氷摩擦係数が,低速度ほど増加する結果は,これまでの伝統的な凝着理論,すなわち摩擦面の氷の塑性流動だけでは説明できない.氷・花崗岩の摩擦係数は,速度を10-3m/sから10-6m/sまで減少させるにつれて,はじめ増加した後に減少した.氷 ...
Shigeki KANAZAWA +2 more
openaire +2 more sources
Ice-Cover and Jamming Effects on Inline Structures and Upstream Water Levels
, 2017 River ice cover is a reoccurring phenomenon in the Northern United States every year. Sheets and layers of ice result in a rise of water surface elevation and may lead to ice jams in a river.
Ahmad, Sajjad +3 more
core +1 more source
A dynamic ice-structure interaction model for ice-induced vibrations by using Van der Pol equation [PDF]
, 2016 A dynamic single degree-of-freedom ice-structure interaction model is developed based on a novel physical mechanism combination between self-excited vibration and forced vibration.
Ji, Xu, Oterkus, Erkan
core +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Direct determination of the air-sea CO₂ gas transfer velocity in Arctic sea-ice regions [PDF]
, 2017 The Arctic Ocean is an important sink for atmospheric CO₂. The impact of decreasing sea-ice extent and expanding marginal ice zones on Arctic air-sea CO₂ exchange depends on the rate of gas transfer in the presence of sea ice.
Anderson, LG +8 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
, 2017 The friction of a stationary moving skate on smooth ice is investigated, in particular in relation to the formation of a thin layer of water between skate and ice.
van Leeuwen, J. M. J.
core +4 more sources