Results 81 to 90 of about 302,803 (284)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

The Statistical Properties of Sea Ice Velocity Fields

Journal of Climate, 2017
By arguing that the surface pressure field over the Arctic Ocean can be treated as an isotropic, stationary, homogeneous, Gaussian random field, Thorndike estimated a number of covariance functions from two years of data (1979 and 1980). Given the active interest in changes of general circulation quantities and indices in the polar regions during the ...
Agarwal, Sahil, Wettlaufer, John S.
openaire   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Revealing sub-{\mu}m inhomogeneities and {\mu}m-scale texture in H2O ice at Megabar pressures via sound velocity measurements by time-domain Brillouin scattering [PDF]

, 2014
Time-domain Brillouin scattering technique, also known as picosecond ultrasonic interferometry, which provides opportunity to monitor propagation of nanometers to sub-micrometers length coherent acoustic pulses in the samples of sub-micrometers to tens ...
Bulou, Alain, Castagnede, Bernard, Chigarev, Nikolay, Gasteau, Damien, Gusev, Vitalyi E., Nikitin, Sergey M., Tournat, Vincent, Zerr, Andreas   +7 more
core   +2 more sources

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

On the assimilation of ice velocity and concentration data into large-scale sea ice models [PDF]

, 2007
Data assimilation into sea ice models designed for climate studies has started about 15 years ago. In most of the studies conducted so far, it is assumed that the improvement brought by the assimilation is straightforward.
T. Fichefet, V. Dulière
core   +3 more sources

What Do Large Language Models Know About Materials?

Advanced Engineering Materials, EarlyView.
If large language models (LLMs) are to be used inside the material discovery and engineering process, they must be benchmarked for the accurateness of intrinsic material knowledge. The current work introduces 1) a reasoning process through the processing–structure–property–performance chain and 2) a tool for benchmarking knowledge of LLMs concerning ...
Adrian Ehrenhofer, Thomas Wallmersperger, Gianaurelio Cuniberti   +2 more
wiley   +1 more source

Effects of accretion flow on the chemical structure in the inner regions of protoplanetary disks [PDF]

, 2008
We have studied the dependence of the profiles of molecular abundances and line emission on the accretion flow in the hot ($\ga 100$K) inner region of protoplanetary disks. The gas-phase reactions initiated by evaporation of the ice mantle on dust grains
Aikawa, Aikawa, Aikawa, Aikawa, Aikawa, Bockelee-Morvan, Boogert, Carr, Caselli, Collings, D'Alessio, Dullemond, Dutrey, Dutrey, Garmire, Garrod, Gibb, Gibb, Glassgold, H. Nomura, Hogerheijde, Kominami, Lahuis, Macdonald, Markwick, Mathis, Nakagawa, Nomura, Nomura, Nomura, Nomura, Ohishi, Pavlychenkov, Qi, Rodgers, Sandford, Sano, Schöier, Schöier, Semenov, T. J. Millar, Thi, Wakalem, Watanabe, Willacy, Willacy, Willacy, Woodall, Y. Aikawa, Y. Nakagawa   +49 more
core   +2 more sources

Intermolecular Interactions as Driving Force of Increasing Multiphoton Absorption in a Perylene Diimide‐Based Coordination Polymer

Advanced Functional Materials, EarlyView.
This study uncovers the unexplored role of intermolecular interactions in multiphoton absorption in coordination polymers. By analyzing [Zn2tpda(DMA)2(DMF)0.3], it shows how the electronic coupling of the chromophores and confinement in the MOF enhance two‐and three‐photon absorption.
Simon Nicolas Deger, Anna Mauri, Yang Cui, Sebastian Josef Weishäupl, Ali Deniz Özdemir, Hamad Syed, Aleksandr Ovsianikov, Wolfgang Wenzel, Alexander Pöthig, Jürgen Hauer, Mariana Kozlowska, Roland Augustinus Fischer   +11 more
wiley   +1 more source

Surface velocity and ice discharge of the ice cap on King George Island, Antarctica [PDF]

, 2013
Glaciers on King George Island, Antarctica, have shown retreat and surface lowering in recent decades, concurrent with increasing air temperatures. A large portion of the glacier perimeter is ocean-terminating, suggesting possible large mass losses due ...
Braun, M., Hock, R., Navarro Valero, Francisco Jose, Osmanoğlu, B.   +3 more
core   +3 more sources