Results 41 to 50 of about 7,617 (266)

New ground ice maps for Canada using a paleogeographic modelling approach [PDF]

The Cryosphere, 2019
Ground ice melt caused by climate-induced permafrost degradation may trigger significant ecological change, damage infrastructure, and alter biogeochemical cycles. The fundamental ground ice mapping for Canada is now >20 years old and does not include
H. B. O'Neill, S. A. Wolfe, C. Duchesne
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Creep Buckling of a Wedge-Shaped Floating Ice Plate

Engineering Transactions, 2004
The paper is concerned with the problem of creep buckling of a floating ice plate pressing against a rigid, vertical-walled, engineering structure of a finite length.
R. Staroszczyk, B. Hedzielski
doaj   +1 more source

Tapped lakes as sediment traps in an Arctic delta [PDF]

Proceedings of the International Association of Hydrological Sciences, 2015
Lakes within the Colville River delta in northern Alaska, USA, vary in size from small ponds created by ice-wedge growth to thaw lakes that are as much as three kilometres long and ten metres deep.
J. Walker, M. McGraw
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Formation of Low-Centered Ice-Wedge Polygons and Their Orthogonal Systems: A Review

Geosciences
Ice wedges, which are ubiquitous in permafrost areas, play a significant role in the evolution of permafrost landscapes, influencing the topography and hydrology of these regions. In this paper, we combine a detailed multi-generational, interdisciplinary,
Yuri Shur, Benjamin M. Jones, M. Torre Jorgenson, Mikhail Z. Kanevskiy, Anna Liljedahl, Donald A. Walker, Melissa K. Ward Jones, Daniel Fortier, Alexander Vasiliev   +8 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Fossil Ice Wedges in Hampshire [PDF]

Nature, 1966
THREE large fossil ice wedges have been discovered in a coastal section exposed at Highcliffe in Hampshire (M.R. 215931). They are to be found within the Plateau Gravel in the uppermost part of the cliff at about 100′ O.D. Here 2.4 m of gravels rest on Barton Beds, at this point consisting of an impermeable glauconitic clay. On top of the gravels is an
openaire   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source