Results 61 to 70 of about 71,705 (309)

Middle and Late Pleistocene environmental history of the Marsworth area, south-central England [PDF]

, 2014
To elucidate the Middle and Late Pleistocene environmental history of south-central England, we report the stratigraphy, sedimentology, palaeoecology and geochronology of some deposits near the foot of the Chiltern Hills scarp at Marsworth ...
Adamiec, Andrew Currant, Andrews, Avery, Ballantyne, Barrow, Bascomb, Bates, Bates, Bates, Bowen, Bowen, Bowen, Bowen, Bowen, Bowen, Bowen, Bowen, Bowen, Bridgland, Candy, Candy, Candy, Canti, Christopher P. Green, Clark, Clayden, Coope, Coope, Currant, Danielle C. Schreve, David H. Keen, David Parish, David Q. Bowen, de Deckker, de Rouffignac, EPICA community members, Evans, Evans, Evans, Galbraith, Gibbard, Gibbard, Gibbard, Gibbard, Green, Green, Gregory, Griffiths, Hamblin, Harmer, Harris, Hill, Hiltermann, Holyoak, Horton, Huntley, Ian Candy, Jarvis, John A. Catt, John G. Evans, Jones, Jones, Jouzel, Julian B. Murton, Kandiano, Kaufman, Keen, Keen, Keen, Keen, Keen, Kerney, Kerney, Kirsty Penkman, Linda L. York, Lisiecki, Lister, Lister, Loveday, Maddy, Markey, McManus, Meijer, Meisch, Mejdahl, Michael P. Kerney, Michael R. Frogley, Miller, Miller, Morgan, Mortimore, Murray, Murray, Murray, Murton, Murton, Murton, Murton, Murton, Murton, Oakley, Oches, Pawley, Penkman, Penkman, Penkman, Penkman, Penkman, Peter Worsley, Phillip S. Toms, Preece, Preece, Prescott, Robinson, Rose, Rousseau, Schreve, Sheila Taylor, Shephard-Thorn, Shephard-Thorn, Sherlock, Sherlock, Soil Survey of England and Wales, Sparks, Stathoplos, Straw, Sumbler, Sumbler, Sykes, Wehmiller, Wenban-Smith, Whiteman, Williams, Williams, Williams, Worsley, Zimmerman   +137 more
core   +2 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Formation of Low-Centered Ice-Wedge Polygons and Their Orthogonal Systems: A Review

Geosciences
Ice wedges, which are ubiquitous in permafrost areas, play a significant role in the evolution of permafrost landscapes, influencing the topography and hydrology of these regions. In this paper, we combine a detailed multi-generational, interdisciplinary,
Yuri Shur, Benjamin M. Jones, M. Torre Jorgenson, Mikhail Z. Kanevskiy, Anna Liljedahl, Donald A. Walker, Melissa K. Ward Jones, Daniel Fortier, Alexander Vasiliev   +8 more
doaj   +1 more source

Structural insight into TPX2-stimulated microtubule assembly [PDF]

, 2017
During mitosis and meiosis, microtubule (MT) assembly is locally upregulated by the chromatin-dependent Ran-GTP pathway. One of its key targets is the MT-associated spindle assembly factor TPX2.
Nogales, Eva, Roostalu, Johanna, Surrey, Thomas, Zhang, Rui   +3 more
core   +2 more sources

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Fossil Ice Wedges in Hampshire [PDF]

Nature, 1966
THREE large fossil ice wedges have been discovered in a coastal section exposed at Highcliffe in Hampshire (M.R. 215931). They are to be found within the Plateau Gravel in the uppermost part of the cliff at about 100′ O.D. Here 2.4 m of gravels rest on Barton Beds, at this point consisting of an impermeable glauconitic clay. On top of the gravels is an
openaire   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source