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Design and Verification of a Modified Ichip to Incorporate Coculturing of Soil Microbes; How the political economy hinders antibiotic discovery and how that can be changed

2022
The overwhelming majority microbial species don’t grow on normal laboratory media, which is necessary in order to study their biology. There are many different strategies that aim to grow these “unculturable” microbes, with one such strategy being the ichip.
openaire   +1 more source

Design and Verification of a Modified Ichip to Incorporate Coculturing of Soil Microbes; Examining the Process of Research to Grow Unculturable Microbes using Actor Network Theory

2022
There is a rise in antibiotic-resistance infections leading to poor efficacy of current treatments with antibiotics. Bacterial infections that may have been easily treated with antibiotics are now unable to be treated. This crisis has developed due to the overuse and misuse of antibiotics in addition to less and less new drug development.
openaire   +1 more source

Unlocking the Pandora’s Box of Uncultivable Microbes: The “iChip” As A Gateway to Antimicrobial Drug Discovery

International Journal of Research Publication and Reviews, 2023
Millicent Anne Luceño   +6 more
openaire   +1 more source

In Situ Isolation and Culturing of Recalcitrant Soil Bacteria using an Isolation Chip (iChip).

Journal of visualized experiments : JoVE
Ecosystems harbor millions of environmental microbes, some of them capable of producing biotechnologically relevant products such as enzymes, vitamins, amino acids, organic acids, anti-parasitic agents, and antimicrobial agents. Most of these environmental bacteria are deemed "unculturable" as the laboratory culturing methods fail to meet their ...
Antony, Vincy   +3 more
openaire   +1 more source

iChip-Inspired Isolation, Bioactivities and Dereplication of Actinomycetota from Portuguese Beach Sediments

Microorganisms, 2022
Olga Maria Lage   +2 more
exaly  

Systematic Review and Quantitative Comparative Analysis of Antimicrobial Efficacy, Target Binding, and Resistance Profiles of iChip-Derived Compounds, Including Teixobactin and Its Analogs

Microbial Bioactives
The accelerating crisis of antimicrobial resistance (AMR) has, in recent years, forced a reconsideration of how antibiotics are discovered, optimized, and ultimately deployed. Within this shifting landscape, iChip technology—by enabling access to previously unculturable microorganisms—has emerged as a quietly transformative tool. This systematic review
openaire   +1 more source

An Ichip-Domesticated Sponge Bacterium Produces an N-Acyltyrosine Bearing an α-Methyl Substituent

Organic Letters, 2019
Russell Kerr   +2 more
exaly  

<em>In Situ</em> Isolation and Culturing of Recalcitrant Soil Bacteria using an Isolation Chip (iChip)

Journal of Visualized Experiments
Antony Vincy   +3 more
openaire   +1 more source

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