Results 71 to 80 of about 86,820 (316)

The NASA Altitude Wind Tunnel (AWT): Its role in advanced icing research and development [PDF]

Currently experimental aircraft icing research is severely hampered by limitations of ground icing simulation facilities. Existing icing facilities do not have the size, speed, altitude, and icing environment simulation capabilities to allow accurate ...
Blaha, B. J., Shaw, R. J.
core   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

The NASA aircraft icing research program [PDF]

The objective of the NASA aircraft icing research program is to develop and make available to industry icing technology to support the needs and requirements for all-weather aircraft designs.
Reinmann, John J., Shaw, Robert J.
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Icing and De-Icing of a Propeller with Internal Electric Blade Heaters [PDF]

An investigation has been made in the NACA Cleveland icing research tunnel to determine the de-icing effectiveness of an experimental configuration of an Internal electric propeller-blade heater.
Lewis, James P., Stevens, Howard C., Jr.
core   +1 more source

Uncertainty Quantification for Airfoil Icing using Polynomial Chaos Expansions [PDF]

, 2014
The formation and accretion of ice on the leading edge of a wing can be detrimental to airplane performance. Complicating this reality is the fact that even a small amount of uncertainty in the shape of the accreted ice may result in a large amount of ...
DeGennaro, Anthony M., Martinelli, Luigi, Rowley, Clarence W.   +2 more
core   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

The influence of ice accretion physics on the forecasting of aircraft icing conditions [PDF]

The physics which control aircraft ice accretion are reviewed in the context of identifying and forecasting hazardous icing conditions. The severity of aircraft icing is found to be extremely sensitive to temperature, liquid water content and droplet ...
Hansman, R. John, Jr.
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Statistical Study of Aircraft Icing Probabilities at the 700- and 500- Millibar Levels over Ocean Areas in the Northern Hemisphere [PDF]

A statistical study is made of icing data reported from weather reconnaissance aircraft flown by Air Weather Service (USAF). The weather missions studied were flown at fixed flight levels of 500 millibars (18,000 ft) and 700 millibars (10,000 ft) over ...
Lewis, William, Mulholland, Donald R., Perkins, Porter J.   +2 more
core   +1 more source