Results 121 to 130 of about 15,787 (297)

Timing of Deep Brain Stimulation and Cognitive Trajectories in GBA1‐Associated Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Individuals with Parkinson's disease (PD) carrying GBA1 variants often develop advanced motor complications that prompt evaluation for deep brain stimulation (DBS). However, concerns about accelerated cognitive decline after DBS in GBA1 carriers complicate clinical decision making.
Evridiki Asimakidou, Micol Avenali, Jan O. Aasly, Mitra Afshari, Roy N. Alcalay, Sharlet Anderson, Carlo Alberto Artusi, Bryan Bernard, Marco Bozzali, Susan Bressman, Giovanna Calandra‐Buonaura, Francesco Cavallieri, Roberto Cilia, Jean‐Christoph Corvol, Antoniangela Cocco, Rob M.A. de Bie, Debra Ehrlich, Roberto Eleopra, Thomas Foltynie, Alessio Di Fonzo, Giulia Giannini, Christopher Goetz, Deborah Hall, Joohi Jimenez‐Shahed, Leonardo Lopiano, Vanessa Lythe, Maria Chiara Malaguti, Francesca Mameli, Graziella Mangone, Karen Marder, M. Maral Mouradian, Augusto Rini, Luisa Sambati, Rachel Saunders‐Pullman, Vicki Lynn Shanker, Francesca Spagnolo, Marie‐Laure Welter, Roberta Zangaglia, Gian Pal, Enza Maria Valente, PARKNET Study Group, Giada Cuconato, Ilaria Palmieri, Alberto Imarisio, Pierfrancesco Mitrotti, Francesca Valentino, Claudio Pacchetti, Gabriele Imbalzano, Claudia Ledda, Silvia Gallo, Pietro Cortelli, Luca Baldelli, Ilaria Cani, Raffaella Minardi, Valerio Carelli, Franco Valzania, Edoardo Monfrini, Filippo Cogiamanian, Chiara Longo, Fabiana Colucci, Luigi M. Romito, Marco Liccari   +61 more
wiley   +1 more source

A robust classifier for the intrinsic consensus molecular subtypes in colorectal cancer

Journal of Translational Medicine
Background An analysis of colorectal cancer epithelial cells showed two intrinsic subtypes called iCMS2 and iCMS3, in addition to the bulk consensus subtypes (CMS1-4).
Petros Tsantoulis, Yourae Hong, Pratyaksha Wirapati, Ting Pu, Allyson M. Peddle, Thomas Mckee, Sabine Tejpar   +6 more
doaj   +1 more source

Pontos polêmicos no ICMS-importação [PDF]

, 2010
O primeiro tópico trata dos aspectos constitucionais do ICMS-Importação. O segundo tópico trata do ICMS nas operações de importação em especial nas operações de importação por conta e ordem de terceiro, demonstrando a guerra fiscal existente entre os ...
Ferreira, Flávio Geraldo
core  

ATXN8OS Intermediate Expansion Acts as a Genetic Modifier in Spinocerebellar Ataxia Type 48 (SCA48/STUB1)

Movement Disorders, EarlyView.
Abstract Background Association between monoallelic STUB1 variant and expanded ATXN8OS alleles was recently reported, suggesting a pathogenic interaction that may influence spinocerebellar ataxia type 48 (SCA48) phenotype. Objectives We investigated the frequency and clinical impact of ATXN8OS in a large cohort of STUB1 carriers compared to individuals
Charlotte Mouraux, Jean‐Loup Méreaux, Claire‐Sophie Davoine, Léna Guillot Noel, Emilien Petit, Quentin Thomas, Adem Nasraoui, Anna Heinzmann, Claire Ewenczyk, Alexis Brice, Alexandra Durr, Giulia Coarelli   +11 more
wiley   +1 more source

Recent Advances in Cryogel Applications for Musculoskeletal Regeneration

Medicinal Research Reviews, EarlyView.
ABSTRACT Hydrogels have been widely used in tissue engineering due to their high‐water content and biocompatibility, yet their densely cross‐linked microstructure inherently limits cell infiltration, mass transport, and mechanical support. Cryogels, formed through partial freezing and crosslinking under subzero conditions, provide unique 3D macroporous
Dohee Kim, Shinwon Kang, Hyejin Jo, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Guerra fiscal

Boletim IBCCRIM
A utilização pelo contribuinte de créditos presumidos instituídos sem convênio interestadual possui reflexos nos Direitos Tributário e Penal, com a presunção de legitimidade dos órgãos públicos, sendo atípica a conduta do contribuinte diante do princípio
Edward Rocha de Carvalho
doaj  

Microglia Ablation and Downstream Effects in the Cerebrospinal Fluid Proteome

PROTEOMICS, EarlyView.
ABSTRACT Disease‐related activation of glial cells leads to changes in the cerebrospinal fluid (CSF) proteome. However, assigning such protein changes to their cellular origins is often difficult. Here, we used microglia (and macrophage) depletion in mice to identify CSF proteins of microglial origin.
Sinja Buchner, Sihui Song, Stephan A. Müller, Yun Chen, Samira Parhizkar, Stefan F. Lichtenthaler, David M. Holtzman, Mathias Jucker, Stephan A. Kaeser   +8 more
wiley   +1 more source

Substituição Tributária ICMS [PDF]

, 2017
Este artigo tem como objetivo demonstrar como o regime Substituição Tributária conseguiu diminuir os índices de sonegações fiscais das empresas e como consequências uma maior arrecadação de imposto do ICMS.
Araújo Filho, Francisco Porto; Faculdades Promove - Icesp
core   +1 more source

Three Spirometry‐Based At‐Risk Phenotypes Predict Incident Airflow Limitation: A Population‐Based Study

Respirology, EarlyView.
Analysing the population‐based KORA and SHIP studies, three spirometric at‐risk subtypes (early airflow limitation, PRISm, and small airway dysfunction) were consistently associated with incident airflow limitation. Their combination in a conceptual framework identified most future cases with high negative predictive value, suggesting potential for ...
Hendrik Pott, Roman Martin, Wilhelm Bertrams, Mustafa Abdo, Margit Heier, Annette Peters, Beate Stubbe, Max Kutzinski, Anne Obst, Ralf Ewert, Dominik Heider, Henry Völzke, Gernot Rohde, Claus F. Vogelmeier, Bernd Schmeck, Stefan Karrasch, on behalf of the KORA‐study group   +16 more
wiley   +1 more source

Reimagining Cryptogenic Stroke Care: Collaborative Care and Inpatient Insertable Cardiac Monitors for Detection of Atrial Fibrillation

Stroke: Vascular and Interventional Neurology
Background Atrial fibrillation (AF) is a known risk factor of ischemic stroke, and AF‐related stroke is twice more likely to be fatal. Long‐term cardiac rhythm monitoring using insertable cardiac monitors (ICMs) has greater diagnostic yield compared with
Nabeel A. Herial, Daniel R. Frisch, Elan Miller, Priyadarshee Patel, Alfredo Munoz, Melissa Warren, Jane Khalife, Shyam Majmundar, Nathan Farkas, Shaista Alam, Robin Dharia, Diana Tzeng, Behzad B. Pavri, Reginald T. Ho, Arnold Greenspon, Rodney Bell, Pascal Jabbour, Robert Rosenwasser   +17 more
doaj   +1 more source