Results 111 to 120 of about 12,584 (234)

Sphingosine‐1‐Phosphate Receptor 1 Promotes Ovarian Cancer Tumorsphere Proliferation and Metastasis

International Journal of Cancer, Volume 159, Issue 3, Page 768-781, 1 August 2026.
In high‐grade serous ovarian cancer, malignant ascites frequently arise as ovarian cancer cells shed from the primary tumor and aggregate into tumorspheres, severely limiting treatment success. To date, little is known about the mechanisms governing tumorsphere endurance and metastasis within the ascites once formed.
Núria Gendrau‐Sanclemente, Agnès Figueras, Ferran Medina‐Jover, Juan A. Marín‐Jiménez, Michelle De Leeuw, Tianyu Dai, Marina Moreno‐Mosquera, Andrea Morales, Marc Guiu, Josefina Casas, José Carlos Perales, Roger R. Gomis, Francesc Viñals   +12 more
wiley   +1 more source

Urinary Volatile Organic Compound Metabolites Are Associated With MASLD/MASH in Humans and Induce Steatosis in Liver Organoids

Liver International, Volume 46, Issue 8, August 2026.
ABSTRACT Background Volatile organic compound (VOC) exposure is an environmental health concern and could, through the liver exposome, be associated with metabolic dysfunction associated steatotic liver disease (MASLD) progression. Methods We analysed NHANES 2017–2020, a U.S.
Laurens A. van Kleef, Xincheng Li, Pengfei Li, Ibrahim Ayada, Yasir J. Abozaid, Jesse Pustjens, Marike Wabbijn, Geert Bezemer, Mohsen Ghanbari, Luc van der Laan, Harry L. A. Janssen, Frank Tacke, Qiuwei Pan, Willem P. Brouwer   +13 more
wiley   +1 more source

Cross‐Linguistic Variations in Word‐Final Position: The Parametric Hierarchies, Connections and Networks

Studia Linguistica, Volume 80, Issue 2, August 2026.
ABSTRACT Word‐final position is widely recognized as a structurally weak and restricted domain, yet languages differ strikingly in how they regulate segments and clusters at the right edge. While some systems categorically prohibit final consonants, others allow only a subset of segments, and still others impose process‐based adjustments such as final ...
Semra Baturay Meral
wiley   +1 more source

Sema3E‐plexinD1 Axis Is a Modulator of Foxp3+ Regulatory T‐Cells in House Dust Mite Model of Asthma

The FASEB Journal, Volume 40, Issue 14, 31 July 2026.
Airway epithelial‐derived Sema3E enhances both the number and proliferation of Foxp3+ regulatory T (Treg) cells in an acute model of asthma. Mechanistically, deletion of PlexinD1, the receptor for Sema3E, specifically in Foxp3+ cells was associated with a breakdown in immune regulation in this model.
Mojdeh Matloubi, Chukwunonso Onyilagha, Lianyu Shan, Sujata Basu, Andrew J. Halayko, Mohamed Almiski, Abdelilah S. Gounni   +6 more
wiley   +1 more source

Second ICOS Release: ICOS Beta version

Delivery of the ICOS beta release also reporting on the technical performance ...
openaire   +1 more source

Real‐world effectiveness of chemotherapy regimens after immunotherapy in patients with advanced melanoma in Spain: Results from the GEM1801 study

Cancer, Volume 132, Issue 14, 15 July 2026.
ABSTRACT Background Chemotherapy schemes have historically shown low efficacy in patients with metastatic melanoma and have been replaced by immunotherapy and targeted therapy. This work aimed to study whether chemotherapy remains an option after progression to immunotherapy in specific contexts.
Miguel‐Ángel Berciano‐Guerrero, Elisabeth Pérez‐Ruiz, Ainara Soria, Javier Medina Martínez, Pablo Ayala de Miguel, Eva Muñoz‐Couselo, Lorena Bellido, Rafael López Castro, Enrique Espinosa, Lourdes Gutiérrez Sanz, Pablo Cerezuela‐Fuentes, Almudena García Castaño, Guillermo Crespo, Teresa Puértolas, Carlos Aguado de la Rosa, Mónica Corral Subias, Begoña Campos Balea, Aida Bujosa Rodríguez, Victor Navarro Pérez, María José Lecumberri, Francisco Ramón García Arroyo, Alberto Jacobo Cunquero Tomás, Karmele Mujika, Luis Antonio Fernández, José Carlos Villa Guzmán, Berta Hernández, Joaquín Fra Rodríguez, José Luis Manzano, Salvador Martín Algarra, Iván Márquez‐Rodas   +29 more
wiley   +1 more source

ULK4 and CDKN2A polymorphisms influence the risk of developing monoclonal gammopathy of undetermined significance

International Journal of Cancer, Volume 159, Issue 2, Page 410-422, 15 July 2026.
What's new? Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic precursor to multiple myeloma, sharing substantial genetic features with overt malignancy. Given evidence implicating autophagy in myeloma risk, this study examined whether genetic variations in autophagy‐related genes influence MGUS susceptibility.
José Manuel Sánchez‐Maldonado, Angelica Macauda, Antonio José Cabrera‐Serrano, Hauke Thomsen, Murat Güler, Rob Ter Horst, Bethany van Guelpen, Pavel Vodicka, Stefano Landi, Subhayan Chattopadhyay, Pelin Ünal, Lucía Ruiz‐Durán, Delphine Casabonne, Hartmut Goldschmidt, Istemi Serin, María Carretero‐Fernández, Elena Cabezudo, Fernando Reyes‐Zurita, Aaron D. Norman, Ramón García‐Sanz, Gabriele Capurso, Per Hoffmann, Ulrika Pettersson‐Kymmer, Francisco Jiménez‐Romera, S. Vincent Rajkumar, Niels Weinhold, Ludmila Vodickova, Christian Langer, Angelika Stein, Abdulkadir Karismaz, Victor Moreno, Markus M. Nöthen, Karl‐Heinz Jöckel, Francesca Tavano, Joaquín Martínez‐López, Shaji K. Kumar, Juan Francisco Gutiérrez‐Bautista, Daniela Basso, Florentin Späth, Yolanda Benavente, Michelle A. T. Hildebrandt, Börge Schmidt, Tereza Sevcikova, Rui Manuel Vieira Reis, Yang Li, Miguel Ángel López‐Nevot, Mihai G. Netea, Daniele Campa, Alyssa Clay‐Gilmour, Susan L Slager, Kari Hemminki, Celine M Vachon, Asta Försti, Federico Canzian, Juan Sainz   +54 more
wiley   +1 more source

Validation of the ICO-OCEX tool for competency-based assessment in ophthalmology residency programs. [PDF]

BMC Med Educ
Gull A, Yasmin R, Mahboob U, Golnik KC, Moin M.   +4 more
europepmc   +1 more source

A 3D In Vitro Model of the Human Hepatobiliary Junction

Advanced Science, Volume 13, Issue 39, 13 July 2026.
A 3D human organoid platform reconstructs the hepatobiliary junction between primary adult hepatocytes and intrahepatic cholangiocytes. These adult hepatobiliary organoids (aHBOs) support directional bile transport from canaliculi to ductule‐like structures, enable quantitative imaging of junction dynamics, and reveal cell‐type‐specific vulnerabilities
Ashley D. Westerfield, Katarzyna A. Grzelak, Katie Katsuyama, Vardhman Kumar, Bess M. Miller, Joa Yun, Jesse Kirkpatrick, David Mankus, Margaret E. Bisher, Abigail K.R. Lytton‐Jean, Z. Gordon Jiang, David D. Lee, Christopher S. Chen, Sangeeta N. Bhatia   +13 more
wiley   +1 more source

Programmable Lipid Functionalization of Nucleic Acid Nanoparticles Modulates Liver Cell-Type Targeting. [PDF]

ACS Appl Mater Interfaces
Kim HM, Omer M, Knappe GA, McMullen P, Le DA, Pasupathy A, Anderson DG, Bathe M.   +7 more
europepmc   +1 more source