Results 1 to 10 of about 12,864 (92)

Development and evaluation of the first-in-class nanobody based PET tracer targeting human inducible T-cell co-stimulator receptor [PDF]

EJNMMI Research
Background Inducible T-cell co-stimulator receptor (ICOS) is a conserved biomarker mainly expressed on activated T cells. It had been proved that PET imaging targeting ICOS was a promising strategy for assessment of immune responses in cancer ...
Jianming Li, Shao Duan, Wei You, Yao Zhao, Weiran Li, Zunyu Xiao, Jianyu Liu   +6 more
doaj   +2 more sources

Aberrant production of soluble inducible T-cell co-stimulator (sICOS) and soluble programmed cell death protein 1 (sPD-1) in patients with chronic hepatitis C

Molecular Medicine Reports, 2013
Previous studies have indicated that immune dysregulation is an important cause of HCV‑mediated damage to the liver. Co‑stimulation signals, including programmed cell death protein 1 (PD‑1) and inducible T‑cell co‑stimulator (ICOS), have been demonstrated to be involved in the pathogenesis of HCV.
Dongsheng, Wang, Ding'an, Zhou, Qin, Du, Qi, Liang, Qiang, Wang, Li, Fang, Guangrong, Wang, Quming, Fan, Beizhong, Liu, Jingguo, Zhou, Zhong, Tang, Hao, Wu, Xiaolan, Guo, Yanmei, Jiao, Guoyuan, Zhang   +14 more
openaire   +5 more sources

CPT1A inhibition alleviates plasmacytoid dendritic cell-mediated immune suppression in colon cancer through fatty acid oxidation modulation [PDF]

Journal for ImmunoTherapy of Cancer
Background The tolerization of plasmacytoid dendritic cells (pDCs) within the tumor microenvironment facilitates immune evasion, thereby significantly limiting the efficacy of cancer immunotherapy.
Jing Wu, Ning Yang, Shan Zhu, Yuan Qiao, Guoxia Zang, Yong-Jun Liu, Jingtao Chen, Qiuyu Wei, Liyan Wang, Helei Wang, Ziyu Ren   +10 more
doaj   +2 more sources

PD-L1 is expressed on human activated naive effector CD4+ T cells. Regulation by dendritic cells and regulatory CD4+ T cells.

PLoS ONE, 2021
The T cell expression of various co-signalling receptors from the CD28 immunoglobulin superfamily (Inducible T cell co-stimulator (ICOS), Programmed cell death 1(PD-1), cytotoxic T lymphocyte associated protein 4 (CTLA-4), B and T lymphocyte attenuator ...
Fabienne Mazerolles, Frédéric Rieux-Laucat   +1 more
doaj   +2 more sources

Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion

eLife, 2021
Viral infections are controlled, and very often cleared, by activated T lymphocytes. The inducible co-stimulator (ICOS) mediates its functions by binding to its ligand ICOSL, enhancing T-cell activation and optimal germinal center (GC) formation.
Guillem Angulo, Jelena Zeleznjak, Pablo Martínez-Vicente, Joan Puñet-Ortiz, Hartmut Hengel, Martin Messerle, Annette Oxenius, Stipan Jonjic, Astrid Krmpotić, Pablo Engel, Ana Angulo   +10 more
doaj   +1 more source

Expression of immune checkpoint molecules programmed death protein 1, programmed death‐ligand 1 and inducible T‐cell co‐stimulator in mycosis fungoides and Sézary syndrome: association with disease stage and clinical outcome*

British Journal of Dermatology, 2022
The relationship between immune checkpoint status and disease outcome is a major focus of research in cutaneous T-cell lymphoma (CTCL), a disfiguring neoplastic dermatological disorder. Mycosis fungoides (MF) and Sézary syndrome (SS) are the two most common types of CTCL.The aim was to evaluate the immune checkpoint markers programmed death protein 1 ...
Cosimo Di Raimondo, Belen Rubio‐Gonzalez, Joycelynne Palmer, Dennis D. Weisenburger, Jasmine Zain, Xiwei Wu, Zhen Han, Steven T. Rosen, Joo Y. Song, Christiane Querfeld   +9 more
openaire   +2 more sources

Targeting immune checkpoints in anti-neutrophil cytoplasmic antibodies associated vasculitis: the potential therapeutic targets in the future

Frontiers in Immunology, 2023
Anti-neutrophil cytoplasmic autoantibodies (ANCA) associated vasculitis (AAV) is a necrotizing vasculitis mainly involving small blood vessels. It is demonstrated that T cells are important in the pathogenesis of AAV, including regulatory T cells (Treg ...
Menglu Pan, Huanhuan Zhao, Ruimin Jin, Patrick S. C. Leung, Zongwen Shuai, Zongwen Shuai   +5 more
doaj   +1 more source

Expression and prognosis of inducible T‐cell co‐stimulator and its ligand in Chinese stage I–III lung adenocarcinoma patients

Animal Models and Experimental Medicine, 2023
Background Immunotherapy has become the fastest‐adopting treatment paradigm for lung cancer with improved survival. By binding with its ligand (inducible T‐cell co‐stimulator and its ligand [ICOSL]), an inducible T‐cell co‐stimulator (ICOS) could ...
Xiao‐Kai Zhan, Xi‐Kun Liu, Sen Zhang, Hong Chen   +3 more
doaj   +1 more source

Pattern of Tumor-Infiltrating Lymphocytes in Mixed Epithelial and Stromal Tumor of the Kidney: A Review of Five Cases

Cells, 2021
Mixed epithelial and stromal tumor of the kidney (MESTK), a benign rare tumor with malignant transformation potential, is thought to be derived from fetal or immature cells originating from the mesonephric and Müllerian ducts. However, due to its rarity,
Hye Won Lee, Hyunwoo Lee, Chanho Park, Won Joon Oh, Tae Jin Kim, Ghee Young Kwon, Seong Il Seo   +6 more
doaj   +1 more source

CD46/CD3 Costimulation Induces Morphological Changes of Human T Cells and Activation of Vav, Rac, and Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase [PDF]

The Journal of Immunology, 2001
Abstract Efficient T cell activation requires at least two signals, one mediated by the engagement of the TCR-CD3 complex and another one mediated by a costimulatory molecule. We recently showed that CD46, a complement regulatory receptor for C3b as well as a receptor for several pathogens, could act as a potent costimulatory molecule
Zaffran, Yona, Destaing, Olivier, Roux, Agnès, Ory, Stéphane, Nheu, Thao, Jurdic, Pierre, Rabourdin-Combe, Chantal, Astier, Anne   +7 more
openaire   +4 more sources