Results 11 to 20 of about 12,963 (191)

Vaccination with a shared oncogenic tumor-self antigen elicits a population of CD8+ T cells with a regulatory phenotype

Human Vaccines & Immunotherapeutics, 2022
Cancer immunotherapy is a powerful tool for inducing antigen-specific antitumor cytotoxic T lymphocytes (CTLs). Next-generation strategies may include vaccination against overexpressed oncogenic tumor-self antigens.
C. Riccay Elizondo, Jennifer D. Bright, Robert K. Bright   +2 more
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The Antigen Presenting Potential of CD21low B Cells

Frontiers in Immunology, 2020
Human CD21low B cells are expanded in autoimmune (AI) diseases and display a unique phenotype with high expression of co-stimulatory molecules, compatible with a potential role as antigen-presenting cells (APCs).
Marlene E. Reincke, Marlene E. Reincke, Kathryn J. Payne, Kathryn J. Payne, Kathryn J. Payne, Ina Harder, Ina Harder, Valentina Strohmeier, Valentina Strohmeier, Valentina Strohmeier, Reinhard E. Voll, Reinhard E. Voll, Klaus Warnatz, Klaus Warnatz, Baerbel Keller, Baerbel Keller   +15 more
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Comorbidity between lung cancer and COVID-19 pneumonia: role of immunoregulatory gene transcripts in high -expressing normal lung

Therapeutic Advances in Medical Oncology, 2022
Background: SARS-CoV-2 (COVID-19) elicits a T-cell antigen-mediated immune response of variable efficacy. To understand this variability, we explored transcriptomic expression of angiotensin-converting enzyme 2 ( ACE2 , the SARS-CoV-2 receptor) and of ...
Vladimir Lazar, Jacques Raynaud, Shai Magidi, Catherine Bresson, Jean-François Martini, Susan Galbraith, Fanny Wunder, Amir Onn, Gerald Batist, Nicolas Girard, Ulrik Lassen, C. S. Pramesh, Amal Al-Omari, Sadakatsu Ikeda, Guy Berchem, Jean-Yves Blay, Benjamin Solomon, Enriqueta Felip, Josep Tabernero, Eitan Rubin, Thierry Philip, Angel Porgador, Ioana Berindan-Neagoe, Richard L. Schilsky, Razelle Kurzrock   +24 more
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Transcriptome profile and clinical characterization of ICOS expression in gliomas

Frontiers in Oncology, 2022
Inducible co-stimulator (ICOS), an immune costimulatory molecule, has been found to play an essential role across various malignancies. This study investigated the transcriptome profile and clinical characterization of ICOS in gliomas.
Jin Wang, Fei Shi, Aijun Shan
doaj   +1 more source

ICOS-Fc as innovative immunomodulatory approach to counteract inflammation and organ injury in sepsis

Frontiers in Immunology, 2022
Inducible T cell co-stimulator (ICOS), an immune checkpoint protein expressed on activated T cells and its unique ligand, ICOSL, which is expressed on antigen-presenting cells and non-hematopoietic cells, have been extensively investigated in the immune ...
Gustavo Ferreira Alves, Ian Stoppa, Eleonora Aimaretti, Chiara Monge, Raffaella Mastrocola, Elisa Porchietto, Giacomo Einaudi, Debora Collotta, Ilaria Bertocchi, Elena Boggio, Casimiro Luca Gigliotti, Nausicaa Clemente, Manuela Aragno, Daniel Fernandes, Carlo Cifani, Christoph Thiemermann, Chiara Dianzani, Umberto Dianzani, Massimo Collino   +18 more
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Lupus susceptibility region containing CTLA4 rs17268364 functionally reduces CTLA4 expression by binding EWSR1 and correlates IFN-α signature

Arthritis Research & Therapy, 2021
Background Dysregulation of T cells mediated immune responses is a hallmark in the development of systemic lupus erythematosus (SLE). Recent genome wide association study (GWAS) revealed the genetic contribution of variants located in the cytotoxic T ...
Yuan-yuan Qi, Xin-yu Zhao, Xin-ran Liu, Yan-na Wang, Ya-ling Zhai, Xiao-xue Zhang, Xiao-yang Wang, Li-jie Zhang, Ya-fei Zhao, Yan Cui, Xiang-hui Ning, Xu-jie Zhou   +11 more
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Autologous Dendritic Cell Therapy in Mesothelioma Patients Enhances Frequencies of Peripheral CD4 T Cells Expressing HLA-DR, PD-1, or ICOS

Frontiers in Immunology, 2018
Introduction: Malignant pleural mesothelioma (MPM) is a malignancy with a very poor prognosis for which new treatment options are urgently needed. We have previously shown that dendritic cell (DC) immunotherapy provides a clinically feasible treatment ...
Pauline L. de Goeje, Pauline L. de Goeje, Yarne Klaver, Yarne Klaver, Margaretha E. H. Kaijen-Lambers, Margaretha E. H. Kaijen-Lambers, Anton W. Langerak, Heleen Vroman, Heleen Vroman, André Kunert, André Kunert, André Kunert, Cor H. J. Lamers, Cor H. J. Lamers, Joachim G. J. V. Aerts, Joachim G. J. V. Aerts, Reno Debets, Reno Debets, Rudi W. Hendriks   +18 more
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Regulatory T cells induced by B cells: a novel subpopulation of regulatory T cells

Journal of Biomedical Science, 2017
Regulatory T cells play a crucial role in the homeostasis of the immune response. In addition to CD4+Foxp3+ regulatory T cells, several subsets of Foxp3- regulatory T cells, such as T helper 3 (Th3) cells and type 1 regulatory T (Tr1) cells, have been ...
Chien-Hui Chien, Bor-Luen Chiang
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Variation in IL-21-secreting circulating follicular helper T cells in Kawasaki disease

BMC Immunology, 2018
Objective Circulating follicular helper T (cTfh) cells are a specialized subset of CD4+ T cells that express the CXC-chemokine receptor 5 (CXCR5).
Meng Xu, Yanfang Jiang, Jian Zhang, Yan Zheng, Deying Liu, Lishuang Guo, Sirui Yang   +6 more
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Enhanced IL-6/phosphorylated STAT3 signaling is related to the imbalance of circulating T follicular helper/T follicular regulatory cells in patients with rheumatoid arthritis

Arthritis Research & Therapy, 2018
Background Follicular helper T (Tfh) cells are specialized in helping B lymphocytes, which play a central role in autoimmune diseases that have a major B cell component, such as in rheumatoid arthritis (RA).
Qian Niu, Zhuo-chun Huang, Xiao-juan Wu, Ya-xiong Jin, Yun-fei An, Ya-mei Li, Huan Xu, Bin Yang, Lan-lan Wang   +8 more
doaj   +1 more source