Development and evaluation of the first-in-class nanobody based PET tracer targeting human inducible T-cell co-stimulator receptor [PDF]
EJNMMI ResearchBackground Inducible T-cell co-stimulator receptor (ICOS) is a conserved biomarker mainly expressed on activated T cells. It had been proved that PET imaging targeting ICOS was a promising strategy for assessment of immune responses in cancer ...
Jianming Li +6 more
doaj +2 more sources
ICOS+ Tregs: A Functional Subset of Tregs in Immune Diseases
Frontiers in Immunology, 2020 Recent studies have reported the pathological effect of ICOS+ T cells, but ICOS signals also widely participate in anti-inflammatory responses, particularly ICOS+ regulatory T (Treg) cells.
Xian-Zhi Xiong
exaly +3 more sources
ICOS Co-Stimulation: Friend or Foe?
Frontiers in Immunology, 2016 Over the last 15 years, the inducible T cell co-stimulator (ICOS) has been implicated in a wide variety of immune outcomes, including the induction and regulation of Th1, Th2, and Th17 immunity.
Daniel J Wikenheiser +2 more
exaly +3 more sources
Integrative analysis of T cell subset-specific ICOS expression and tumor HLA class I/II expression in lung adenocarcinoma: implications for their interaction and clinical outcome [PDF]
Cancer Immunology, ImmunotherapyObjectives Inducible T cell costimulator (ICOS) is a CD28-family costimulatory receptor with bidirectional therapeutic effects on antitumor immunity, and HLA-mediated tumor recognition is essential for effective T cell responses.
Hiroyuki Yamada +11 more
doaj +2 more sources
ICOS+ T helper 2 cells promote the pulmonary fibrosis in systemic sclerosis [PDF]
Molecular MedicineBackground Interstitial lung disease (ILD) is the most frequent complication of systemic sclerosis (SSc), associated with a poor prognosis and limited treatments.
Huimin Zhu +9 more
doaj +2 more sources
Inducible T‐Cell Co‐Stimulator (ICOS) and ICOS Ligand: Dealing With a Two‐Faced Cancer Immunoregulatory System [PDF]
Cancer MedicineBackground ICOS (inducible T‐cell co‐stimulator) and ICOS ligand (ICOSL) are part of an important, complex pathway that can lead to both immune stimulation and suppression.
Mina Nikanjam +9 more
doaj +2 more sources
A view of the European carbon flux landscape through the lens of the ICOS atmospheric observation network [PDF]
Atmospheric Chemistry and Physics, 2023 The ICOS (Integrated Carbon Observation System) network of atmospheric measurement stations produces standardized data on greenhouse gas concentrations at 46 stations in 16 different European countries (March 2023).
I. Storm +6 more
doaj +1 more source
Pifu-xingbing zhenliaoxue zazhi, 2023 Objective To investigate the levels of different follicular helper T cells in peripheral blood of syphilis patients and discuss its clinical significance.
Kaixi PAN +4 more
doaj +1 more source
Versioning biological cells for trustworthy cell engineering
Nature Communications, 2022 Full traceability and transparency are important to establish trust in engineered cell lines. Here the authors argue that version control for cell engineering marks a significant step toward more open, reproducible, traceable and ultimately more ...
Jonathan Tellechea-Luzardo +6 more
doaj +1 more source
Financial Bubbles for Economic Development: Implications Regarding ICOs
Studies in Business and Economics, 2021 Most people consider financial bubbles as the result of speculations and manipulations, and that less of them will make a market economy more efficient. While speculative bubbles no doubt increase the risks and uncertainties of investors, there are many ...
Lorne Frank, Li Tianze
doaj +1 more source