Results 1 to 10 of about 23,238 (188)

Inducible costimulator expression regulates the magnitude of Th2-mediated airway inflammation by regulating the number of Th2 cells. [PDF]

PLoS ONE, 2009
Inducible Costimulator (ICOS) is an important regulator of Th2 lymphocyte function and a potential immunotherapeutic target for allergy and asthma. A SNP in the ICOS 5' promoter in humans is associated with increased atopy and serum IgE in a founder ...
Bryan S Clay, Rebecca A Shilling, Hozefa S Bandukwala, Tamson V Moore, Judy L Cannon, Andrew A Welcher, Joel V Weinstock, Anne I Sperling   +7 more
doaj   +1 more source

ICOS-deficient and ICOS YF mutant mice fail to control Toxoplasma gondii infection of the brain.

PLoS ONE, 2020
Resistance to chronic Toxoplasma gondii infection requires ongoing recruitment of T cells to the brain. Thus, the factors that promote, sustain, and regulate the T cell response to the parasite in the brain are of great interest.
Carleigh A O'Brien, Tajie H Harris
doaj   +1 more source

The Virtual Electrode Recording Tool for EXtracellular Potentials (VERTEX) Version 2.0: Modelling in vitro electrical stimulation of brain tissue [version 1; peer review: 2 approved]

Wellcome Open Research, 2019
Neuronal circuits can be modelled in detail allowing us to predict the effects of stimulation on individual neurons. Electrical stimulation of neuronal circuits in vitro and in vivo excites a range of neurons within the tissue and measurements of neural ...
Christopher Thornton, Frances Hutchings, Marcus Kaiser   +2 more
doaj   +1 more source

A knowledge integration strategy for the selection of a robust multi-stress biomarkers panel for Bacillus subtilis

Synthetic and Systems Biotechnology, 2023
One challenge in the engineering of biological systems is to be able to recognise the cellular stress states of bacterial hosts, as these stress states can lead to suboptimal growth and lower yields of target products.
Yiming Huang, Nishant Sinha, Anil Wipat, Jaume Bacardit   +3 more
doaj   +1 more source

Investigating the differences in calculating global mean surface CO₂ abundance: the impact of analysis methodologies and site selection [PDF]

Atmospheric Chemistry and Physics
The World Meteorological Organization (WMO) Global Atmosphere Watch (GAW) coordinates high-quality atmospheric greenhouse gas observations globally and provides these observations through the WMO World Data Centre for Greenhouse Gases (WDCGG) supported ...
Z. Wu, Z. Wu, A. Vermeulen, Y. Sawa, U. Karstens, U. Karstens, W. Peters, W. Peters, R. de Kok, R. de Kok, X. Lan, X. Lan, Y. Nagai, A. Ogi, O. Tarasova   +14 more
doaj   +1 more source

ICOS regulates the generation and function of human CD4+ Treg in a CTLA-4 dependent manner. [PDF]

PLoS ONE, 2013
Inducible co-stimulator (ICOS) is a member of CD28/Cytotoxic T-lymphocyte Antigen-4 (CTLA-4) family and broadly expressed in activated CD4(+) T cells and induced regulatory CD4(+) T cells (CD4(+) iTreg).
Jian Zheng, Ping-Lung Chan, Yinping Liu, Gang Qin, Zheng Xiang, Kwok-Tai Lam, David B Lewis, Yu-Lung Lau, Wenwei Tu   +8 more
doaj   +1 more source

Inducible T-Cell Costimulator Mediates Lymphocyte/Macrophage Interactions During Liver Repair

Frontiers in Immunology, 2021
The liver capacity to recover from acute liver injury is a critical factor in the development of acute liver failure (ALF) caused by viral infections, ischemia/reperfusion or drug toxicity.
Naresh Naik Ramavath, Laila Lavanya Gadipudi, Alessia Provera, Luca C. Gigliotti, Elena Boggio, Cristina Bozzola, Emanuele Albano, Umberto Dianzani, Salvatore Sutti   +8 more
doaj   +1 more source

Inducible Costimulator Gene-Transduced Bone Marrow-Derived Mesenchymal Stem Cells Attenuate the Severity of Acute Graft-Versus-Host Disease in Mouse Models

Cell Transplantation, 2015
In murine allogeneic transplantation models, ICOS gene-transduced bone marrow-derived mesenchymal stem cells (MSCs ICOS-EGFP ) were evaluated for their effects on GvHD severity and long-term survival. Lethally irradiated BALB/c or first filial generation
Dan Yang, Li-Ping Wang, Hong Zhou, Hui Cheng, Xiao-Chen Bao, Sheng Xu, Wei-Ping Zhang, Jian-Min Wang   +7 more
doaj   +1 more source

Pilot Study of Delayed ICOS/ICOS-L Blockade With αCD40 to Modulate Pathogenic Alloimmunity in a Primate Cardiac Allograft Model

Transplantation Direct, 2018
Background. Inducible costimulator (ICOS) is rapidly upregulated with T-cell stimulation and may represent an escape pathway for T-cell costimulation in the setting of CD40/CD154 costimulation blockade.
Natalie A. O’Neill, MD, Tianshu Zhang, MD, PhD, Gheorghe Braileanu, PhD, Xiangfei Cheng, MD, PhD, Alena Hershfeld, MS, Wenji Sun, MD, PhD, Keith A. Reimann, PhD, Sia Dahi, MD, Natalia Kubicki, MD, Wessam Hassanein, MD, Christopher Laird, MD, Arielle Cimeno, MD, Agnes M. Azimzadeh, PhD, Richard N. Pierson, MD   +13 more
doaj   +1 more source

T cell receptor signaling defines the fate and pathway of ICOS internalization

Biochemistry and Biophysics Reports, 2020
The role of the inducible costimulatory of T cells (ICOS) has been shown to be important for many different T cell outcomes and is indispensable for follicular helper T cell (TFH) responses.
Joseph C. Lownik, Daniel H. Conrad, Rebecca K. Martin   +2 more
doaj   +1 more source