Results 41 to 50 of about 29,154 (297)

A knowledge integration strategy for the selection of a robust multi-stress biomarkers panel for Bacillus subtilis

Synthetic and Systems Biotechnology, 2023
One challenge in the engineering of biological systems is to be able to recognise the cellular stress states of bacterial hosts, as these stress states can lead to suboptimal growth and lower yields of target products.
Yiming Huang, Nishant Sinha, Anil Wipat, Jaume Bacardit   +3 more
doaj   +1 more source

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

Note on the compatibility of ICOS, NEON, and TERN sampling designs, different camera setups for effective plant area index estimation with digital hemispherical photography

Metsanduslikud Uurimused
Environmental monitoring networks such as the Integrated Carbon Observation System (ICOS) in Europe, the National Ecological Observatory Network (NEON) in the U.S., or the Terrestrial Ecosystem Research Network (TERN) in Australia deploy different ...
Kaha Mihkel, Lang Mait, Zhang Shaohui, Pisek Jan   +3 more
doaj   +1 more source

Involvement of CD40-CD40L and ICOS-ICOSL in the development of chronic rhinosinusitis by targeting eosinophils

Frontiers in Immunology, 2023
BackgroundChronic rhinosinusitis (CRS), whose prevalence and pathogenesis are age-related, is characterized by nasal tissue eosinophil infiltration.
Aina Zhou, Chenxi Shi, Yuhui Fan, Yushuang Zheng, Jue Wang, Zhichen Liu, Huanxia Xie, Jisheng Liu, Qingqing Jiao   +8 more
doaj   +1 more source

Effect of CXCR5, PD-1 and ICOS on B-cell responses and relevance to myasthenia gravis. [PDF]

Clin Transl Immunology
This study compared the efficacy of PD‐1 and ICOS molecules in antibody production within CXCR5+ and CXCR5− CD4+ T cells; it demonstrates that PD‐1+ T cells provide the most effective B cell support, a finding also validated in autoantibody production in myasthenia gravis.
Çebi M, Çakar A, Durmuş H, Parman Y, Saruhan-Direskeneli G.   +4 more
europepmc   +2 more sources

ICOS-deficiency is linked to a defect in NK cell number and survival.

, 2019
(A) Representative dot-plots showing the strategy to select different subpopulations (T, NKT and NK) in the spleen of WT and ICOS-KO mice. NK cells (NK) were gated as CD3-NK1.1+ILC- to exclude ILC as indicated in Methods.
Umberto Dianzani (84558), María Montes-Casado (4891237), Laura Aragoneses-Fenoll (4891246), Pilar Portolés (4891240), Gloria Ojeda (4891234), Daniel López (279575), José M. Rojo (4891243), María Luisa Gaspar (843397), Belén de Andrés (843396)   +8 more
core   +1 more source

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

A novel combination of chemotherapy and immunotherapy controls tumor growth in mice with a human immune system

OncoImmunology, 2019
Mice reconstituted with a human immune system and bearing human tumors represent a promising model for developing novel cancer immunotherapies. Here, we used mass cytometry and multi-parametric flow cytometry to characterize human leukocytes infiltrating
Aude Burlion, Rodrigo N. Ramos, Pukar KC, Kélhia Sendeyo, Aurélien Corneau, Christine Ménétrier-Caux, Eliane Piaggio, Daniel Olive, Christophe Caux, Gilles Marodon   +9 more
doaj   +1 more source

Comprehensive analysis of the role of ICOS ( CD278 ) in pan-cancer prognosis and immunotherapy

BMC Cancer, 2023
Background The immunological checkpoint known as Inducible T Cell Costimulatory Factor (ICOS, Cluster of Differentiation, CD278) is activated and expressed on T cells. Both somatic cells and antigen-presenting cells expressed its ligand, ICOSL (including
Xiashuang Zhao, Yongfeng Wang, Xianglai Jiang, Bangqian Mo, Chenyu Wang, Mingzheng Tang, Yao Rong, Guiqian Zhang, Ming Hu, Hui Cai   +9 more
doaj   +1 more source

Toward Nano‐Nutritional Medicine: A Remotely Activated Trans‐Vaccenic Acid‐Based Lipid Nanoparticles for Enhancing Immune Checkpoint Blockade Therapy

Advanced Science, EarlyView.
Eutectic mixtures from trans‐vaccenic acid (TVA) and stearic acid, which served as phase‐change material to encapsulate IR780, forming NIR‐responsive nanoparticles. IR780@TVA LNPs induce photothermal therapy and initiate adaptive anti‐tumor immunity.
Kang Liu, Yunlong Li, Hanmeng Liu, Peng Zhang, Mingjing Wang, Quanwei Sun, Wenshuo Yang, Zhengwei Song, Song Tan, Ye Yang, Peng She, Dengke Yin, Wei Shen   +12 more
wiley   +1 more source