Results 51 to 60 of about 23,238 (188)

Single‐Cell Insights Into Pathogenic Profile of Orchitis and SREBP2‐Associated Cholesterol Dysregulation in Spermatogenic Failure

Advanced Science, EarlyView.
A first single‐cell atlas of human orchitis reveals coordinated germ‐cell loss, somatic niche dysfunction, and immune‐metabolic remodeling. Aberrant SREBP2 activation in testicular somatic cells emerges as a central pathogenic node, while Fatostatin‐mediated inhibition of the SREBP pathway improves spermatogenesis, fibrosis, and lipid accumulation in a
Yanlin Tang, Qiaoling Jiang, Yuwen Liu, Wenxiu Zhang, Lina Cui, Xiaojian Lu, Ziyan Zhuang, Jianxing Cheng, Songzhan Gao, Yangyi Fang, Kai Hong, Jie Qiao, Xiaoyan Wang, Hui Jiang, Zhe Zhang, Jingtao Guo, Qiang Liu   +16 more
wiley   +1 more source

18F‐FGln PET/CT Imaging of Glutamine Uptake Has Potential for Predicting Immunotherapy Response in Hepatocellular Carcinoma

Advanced Science, EarlyView.
18F‐FGln PET/CT imaging serves as a marker of Gln uptake in hepatocellular carcinoma. Tumors with high Gln uptake drive Treg‐mediated immunosuppression and immune evasion during antitumor immunotherapy. Conversely, tumors with low Gln uptake maintain sufficient Gln in the TME, suppressing Tregs and enabling cytotoxic T cells to inhibit tumor growth ...
Yi Liu, Jindian Li, Xiaoyu Pan, Xiaoping Xu, Xuan Huang, Simin He, Jianping Zhang, Fei Liu, Shaoli Song   +8 more
wiley   +1 more source

Histological description and bone compactness analysis of fossil (Aldabrachelys sp.) and extant Aldabra giant tortoise (Aldabrachelys gigantea) shell bone fragments

The Anatomical Record, EarlyView.
Abstract Aldabra Atoll, north of Madagascar and part of the Seychelles Outer Islands, is home to the Aldabra giant tortoise, Aldabrachelys gigantea, the only survivor of several species of giant tortoises that were once widespread on islands across the Western Indian Ocean.
Stefanie Herter, Nicole Klein, Massimo Delfino, Erik de Boer, Julian P. Hume, Jordan Bestwick, Frauke Fleischer‐Dogley, Annabelle Constance, Dennis M. Hansen, Torsten M. Scheyer   +9 more
wiley   +1 more source

The synergistic impact of granulocytic myeloid‐derived suppressor cells and innate lymphoid cells in systemic sclerosis

Arthritis &Rheumatology, Accepted Article.
Objective Systemic sclerosis (SSc) is a chronic autoimmune disorder characterized by immune dysregulation and fibrosis, with myeloid‐derived suppressor cells (MDSCs) emerging as important regulators of immune responses. However, the role of MDSCs in SSc‐associated fibrosis and their interactions with other immune cell populations remain poorly ...
Stefanie Weber, Mario R. Angeli, Hashem Mohammadian, Hannah Labinsky, Maria Gabriella Raimondo, Richard Demmler, Yuko Ariza, Thomas Wohlfahrt, Markus Luber, Yi‐Nan Li, Jörg H.W. Distler, Tobias Bäuerle, Georg Schett, Simon Rauber, Andreas Ramming, Alina M. Ramming   +15 more
wiley   +1 more source

Synovial Tissue‐Guided Interleukin‐17A Inhibition for Refractory Arthritis in a Patient With Systemic Juvenile Idiopathic Arthritis

Arthritis &Rheumatology, Accepted Article.
Objective The objective of this study was to characterize the clinical, immunologic, and synovial tissue features of a patient with a systemic juvenile idiopathic arthritis (sJIA) who carries a novel heterozygous STAT5B loss‐of‐function variant (p.Gln139Ter) and whose arthritis responded markedly to interleukin‐17A (IL‐17A) inhibition.
Indira Sriram, Tomohiro Kawabe, Hitoshi Irabu, Mariana Correia Marques, Clara Lin, Alisa Gaskell, Jun Inamo, Michael R. Clay, Roselyn Fierkens, Robert C. Fuhlbrigge, Jeremy D. Prager, Norman R. Friedman, Sarah A. Gitomer, Michael J. Ombrello, Kentaro Yomogida   +14 more
wiley   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

The Effect of Water Management and Cell Compression in Bipolar Membrane CO2 Electrolysis to CO

Carbon Energy, EarlyView.
In‐operando neutron imaging uncovers water management challenges in bipolar membrane CO2 electrolysis: Internal water generation floods the cathode, while compression dictates membrane and gas diffusion electrode integrity. Strategic adjustments are applied in this work: dry gas feed and mechanical support of the gas diffusion electrode enable stable ...
Frederik Brendel, Liel Bühler, Luca Bohn, Josephine N. Häberlein, Lukas Helfen, Alessandro Tengattini, Severin Vierrath, Joey Disch   +7 more
wiley   +1 more source

Bacterial Species Associated With Chronic Inflammation and Oral Cancer. A Comparative Study Between Patients With HNC and Patients With Chronic Periodontitis

Cancer Nexus, EarlyView.
ABSTRACT Objective To compare the presence and quantification of selected periodontopathogenic bacterial species and salivary parameters between patients with head and neck cancer (HNC) treated with radiotherapy and patients with chronic periodontitis, using chronic periodontitis as a reference model of oral dysbiosis.
Tanya Pereira‐Riveros, José López‐López, Alicia Lozano‐Borbalas, Julio Paciello‐Coronel, Teresa Vinuesa   +4 more
wiley   +1 more source

Mapping the Intellectual Structure of AI‐Driven ESG Cost Modeling: A Bibliometric Analysis of Trends, Themes, and Future Directions

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT The bibliometric and qualitative analyses of 470 publications in the Web of Science Core Collection from 2004 through 2025 in this study associated the intellectual structure and thematic evolution of AI‐driven ESG cost modeling. The research commences using an integrated analytical framework consisting of three tools: (1) Bibliometrix (R) for
Nesreen Al‐Malkawi, Adriana Giret
wiley   +1 more source

Developing a Suitable Anion Exchange Layer Structure for Pure–Water Fed Bipolar Membrane CO2 Electrolysis

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
A porous anion exchange layer (AEL) is implemented in a forward‐biased bipolar membrane CO2 electrolyzer to suppress carbonate crossover, support CO2 regeneration and maintain cathode alkalinity. Two fabrication strategies are compared—deposition on a silver gas diffusion electrode (GDE) or on the CEM—showing that a porous AEL‐coated GDE provides the ...
Henning Lorenz, Nico Roubicek, Simon Thiele, Chuyen van Pham   +3 more
wiley   +1 more source