Results 71 to 80 of about 29,154 (297)

Inducible Costimulator Expressing T Cells Promote Parasitic Growth During Blood Stage Plasmodium berghei ANKA Infection

Frontiers in Immunology, 2018
The lethality of blood stage Plasmodium berghei ANKA (PbA) infection is associated with the expression of T-bet and production of cytokine IFN-γ. Expression of inducible costimulator (ICOS) and its downstream signaling has been shown to play a critical ...
Gajendra M. Jogdand, Soumya Sengupta, Gargee Bhattacharya, Santosh Kumar Singh, Prakash Kumar Barik, Satish Devadas   +5 more
doaj   +1 more source

The interplay between molecular architecture, pharmacology, and suspected adverse drug reactions associated with nonsteroidal androgen antagonists in the United Kingdom

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to correlate potential links between the suspected adverse drug reaction (ADR) profile of licensed nonsteroidal androgen receptor antagonists (NSARA) with their unique chemical properties and known off‐target polypharmacology. Methods Physicochemical and polypharmacology data were curated from the Electronic Medicines Compendium ...
Simrit Dhillon, Albert A. Antolin, Alan M. Jones   +2 more
wiley   +1 more source

The Virtual Electrode Recording Tool for EXtracellular Potentials (VERTEX) Version 2.0: Modelling in vitro electrical stimulation of brain tissue [version 1; peer review: 2 approved]

Wellcome Open Research, 2019
Neuronal circuits can be modelled in detail allowing us to predict the effects of stimulation on individual neurons. Electrical stimulation of neuronal circuits in vitro and in vivo excites a range of neurons within the tissue and measurements of neural ...
Christopher Thornton, Frances Hutchings, Marcus Kaiser   +2 more
doaj   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

2023Kim-ICOS-Tph

, 2023
Fine-mapping and functional studies implicate rs117701653, a common non-coding variant in the CD28/CTLA4/ICOS locus, as a contributor to risk for rheumatoid arthritis and type 1 diabetes.
Nigrovic, P (via Mendeley Data)
core   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Investigating the differences in calculating global mean surface CO₂ abundance: the impact of analysis methodologies and site selection [PDF]

Atmospheric Chemistry and Physics
The World Meteorological Organization (WMO) Global Atmosphere Watch (GAW) coordinates high-quality atmospheric greenhouse gas observations globally and provides these observations through the WMO World Data Centre for Greenhouse Gases (WDCGG) supported ...
Z. Wu, Z. Wu, A. Vermeulen, Y. Sawa, U. Karstens, U. Karstens, W. Peters, W. Peters, R. de Kok, R. de Kok, X. Lan, X. Lan, Y. Nagai, A. Ogi, O. Tarasova   +14 more
doaj   +1 more source

Resource‐Centered Transformation Paths: The Role of Digital Transformation in Optimizing SME Resources for Sustainable Entrepreneurship

Business Strategy and the Environment, EarlyView.
ABSTRACT The critical role of small and medium‐sized enterprises (SMEs) in driving economic growth through employment generation and innovation cannot go unseen, especially the efforts of small firms in promoting sustainable entrepreneurship. With more market and consumer focus on sustainability and the shift toward eco‐friendly products, SMEs can ...
Nasser Hadi Alajmi
wiley   +1 more source

Developing a Suitable Anion Exchange Layer Structure for Pure–Water Fed Bipolar Membrane CO2 Electrolysis

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
A porous anion exchange layer (AEL) is implemented in a forward‐biased bipolar membrane CO2 electrolyzer to suppress carbonate crossover, support CO2 regeneration and maintain cathode alkalinity. Two fabrication strategies are compared—deposition on a silver gas diffusion electrode (GDE) or on the CEM—showing that a porous AEL‐coated GDE provides the ...
Henning Lorenz, Nico Roubicek, Simon Thiele, Chuyen van Pham   +3 more
wiley   +1 more source

Cardiovascular toxicity induced by TKIs in patients with chronic myeloid leukaemia: Are women and men different?

ESC Heart Failure, Volume 12, Issue 2, Page 1447-1454, April 2025.
This study analyzes 148 patients (66 women and 82 men) with chronic myeloid leukemia treated with tyrosine kinase inhibitors, focusing on cardiovascular adverse events. The risk assessment, performed using the HFA/ICOS score, reveals sex‐specific differences: venous thrombosis is more common in women, while arterial thrombosis predominates in men.
Cristina Madaudo, Daniela Di Lisi, Antonio Cannatà, Federica Manfrè, Celeste Vullo, Marco Santoro, Ciro Botta, Salvatrice Mancuso, Sergio Siragusa, Alfredo Ruggero Galassi, Giuseppina Novo   +10 more
wiley   +1 more source