Results 61 to 70 of about 29,154 (297)

Pilot Study of Delayed ICOS/ICOS-L Blockade With αCD40 to Modulate Pathogenic Alloimmunity in a Primate Cardiac Allograft Model

Transplantation Direct, 2018
Background. Inducible costimulator (ICOS) is rapidly upregulated with T-cell stimulation and may represent an escape pathway for T-cell costimulation in the setting of CD40/CD154 costimulation blockade.
Natalie A. O’Neill, MD, Tianshu Zhang, MD, PhD, Gheorghe Braileanu, PhD, Xiangfei Cheng, MD, PhD, Alena Hershfeld, MS, Wenji Sun, MD, PhD, Keith A. Reimann, PhD, Sia Dahi, MD, Natalia Kubicki, MD, Wessam Hassanein, MD, Christopher Laird, MD, Arielle Cimeno, MD, Agnes M. Azimzadeh, PhD, Richard N. Pierson, MD   +13 more
doaj   +1 more source

Radiation measurements at ICOS ecosystem stations [PDF]

, 2018
Solar radiation is a key driver of energy and carbon fluxes in natural ecosystems. Radiation measurements are essential for interpreting ecosystem scale greenhouse gases and energy fluxes as well as many other observations performed at ecosystem stations
Sabbatini, Simone, Ibrom, A., Serrano-Ortiz, Penelope, Arriga, Nicola, Biraud, S.C., Carrara, Arnaud, Berveiller, Daniel, Rebmann, Corinna, Carrara, A., Biraud, Sébastien C, Biraud, Sebastien C., Kolari, P., Dengel, Sigrid, Berveiller, D., Beeck, M. de, Op the Beeck, M., Kolari, Pasi, Op de Beeck, Maarten, Serrano-Ortiz, P., Rebmann, C., de Beeck, Maarten Op, Merbold, Lutz, Ibrom, Andreas, Merbold, L., Arriga, N., Dengel, S., Biraud, Sébastien, Sabbatini, S., Serrano Ortíz, P.   +28 more
core   +1 more source

Quizartinib in Combination With FLAG‐IDA for Relapsed or Refractory Acute Myeloid Leukemia (FLAG‐QUIDA): A PETHEMA Phase I‐II Trial

American Journal of Hematology, EarlyView.
ABSTRACT Quizartinib is a tyrosine kinase inhibitor with single agent activity in patients with relapsed or refractory (R/R) acute myeloid leukemia (AML) and has demonstrated efficacy in first‐line therapy when combined with intensive chemotherapy in both FLT3 ITD‐negative and positive AML.
Teresa Bernal, Javier Zambrano Márquez, Rebeca Rodríguez‐Veiga, Eduardo Rodríguez‐Arbolí, Juan Manuel Bergua‐Burgués, Susana Vives, Montserrat Arnán, Pilar Martínez Sánchez, Pilar Herrera‐Puente, Josefina Serrano‐López, Vicente Rubio, Inmaculada Marchante‐Cepillo, Marta Cervera‐Calvo, Andrés Novo García, Rosa Fernández Martín, Cristina Gil Cortés, Carlos Rodríguez‐Medina, Victor Noriega‐Concepción, Ana Alfonso‐Piérola, Carmen Loredo, María Antuña‐Casal, Blanca Boluda, Isabel Cano‐Ferri, Evelyn Acuña‐Cruz, Laura Torres‐Miñana, Joaquín Sánchez‐García, Cristina Bilbao, Maria Teresa Gómez‐Casares, David Martínez Cuadrón, Pau Montesinos   +29 more
wiley   +1 more source

Treasury Consultation Paper on ICOs in Australia: The Technology, The Market, and The Regulation of ICOs (Working paper)

, 2019
The Australian Treasury has identified a number of challenges in FinTech, especially around Initial Coin Offerings (ICOs). In this paper we examine four types of tokens within ICOs: pure utility tokens, security tokens, stored value tokens, and hybrid ...
Flood, John, McCullagh, Adrian
core   +1 more source

Multi‐Omic Profiling Reveals Immune Cell Priming Signature Linked to Lupus Prognosis

Arthritis &Rheumatology, EarlyView.
Objective Systemic lupus erythematosus (SLE) is a multiorgan disease with widespread immune dysregulation and significant unmet clinical need. Blood‐based gene expression studies have advanced our understanding of SLE pathogenesis but may overlook critical tissue‐specific mechanisms that drive disease heterogeneity and progression.
Michael A. Smith, Dominic Sinibaldi, Saifur Rahman, Chia‐Chien Chiang, Anna M. Hansen, Jill Henault, Carlos P. Roca, Shu Wang, Kamelia Zerrouki, Rebecca Filippi, Christopher Groves, Zerai Manna, Jun Chu, Michael Davis, Sarthak Gupta, Christopher Morehouse, Melissa de los Reyes, Rachel Ettinger, Roland Kolbeck, Mariana J. Kaplan, Miguel A. Sanjuan, Richard M. Siegel, Sarfaraz A. Hasni, Kerry A. Casey   +23 more
wiley   +1 more source

Inducible Costimulator Gene-Transduced Bone Marrow-Derived Mesenchymal Stem Cells Attenuate the Severity of Acute Graft-Versus-Host Disease in Mouse Models

Cell Transplantation, 2015
In murine allogeneic transplantation models, ICOS gene-transduced bone marrow-derived mesenchymal stem cells (MSCs ICOS-EGFP ) were evaluated for their effects on GvHD severity and long-term survival. Lethally irradiated BALB/c or first filial generation
Dan Yang, Li-Ping Wang, Hong Zhou, Hui Cheng, Xiao-Chen Bao, Sheng Xu, Wei-Ping Zhang, Jian-Min Wang   +7 more
doaj   +1 more source

ICOS-KO mice show a defective NK cell-dependent in vivo response against Vaccinia virus.

, 2019
Analysis of the in vivo NK cell response to vaccinia virus in WT, ICOS-KO mice or NK-depleted WT mice by i.v. injection of anti-asialo-GM1 Ab (as described in Methods section).
Umberto Dianzani (84558), María Montes-Casado (4891237), Laura Aragoneses-Fenoll (4891246), Pilar Portolés (4891240), Gloria Ojeda (4891234), Daniel López (279575), José M. Rojo (4891243), María Luisa Gaspar (843397), Belén de Andrés (843396)   +8 more
core   +1 more source

Single‐Cell Level Characterization of B Cell Depletion and Repopulation Following Rituximab in Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective Rituximab, a CD20+ B cell depletion therapy, is frequently used to treat systemic lupus erythematosus (SLE). However, variability in patient response highlights the need for a deeper understanding of the underlying immune cell dynamics of B cell depletion and repopulation.
Haerin Jang, Norzawani Buang, Catherine Sutherland, Wanseon Lee, Lauren Overend, Tarran S. Rupall, Katie L. Burnham, Matthew C. Pickering, Marina Botto, Emma E. Davenport   +9 more
wiley   +1 more source

ICOS Sweden station presentation poster

, 2016
ICOS - Integrated Carbon Observation System - is a European research infrastructure to quantify and understand the greenhouse gas balance of the European continent and of adjacent regions.
Nilsson, Mats (5297626), Mölder, Meelis (5297635), Lindroth, Anders, Crill, Patrick, Weslien, Per, Heliasz, Michal (5297623), Rutgersson, Anna (5297620), Lindroth, Anders (5297644), Ottosson Löfvenius, Mikaell, Crill, Patrick (5297647), Ottosson Löfvenius, Mikaell (5297629), Klemedtsson, Leif (5297632), Klemedtsson, Leif, Friborg, Thomas (5297641), ICOS Sweden, Nilsson, Mats, Heliasz, Michal, Mölder, Meelis, ICOS Sweden (5297617), Rutgersson, Anna, Friborg, Thomas, Weslien, Per (5297638)   +21 more
core   +1 more source

Distinct molecular pathways supporting Sjögren's Disease clusters and disease progression.

Arthritis &Rheumatology, Accepted Article.
Objective Sjögren's disease (SjD) is a heterogeneous autoimmune disease. We aimed to investigate blood transcriptomic signatures and disease progression among three recently defined SjD patient clusters: (1) B‐cell active with low symptoms (BALS), (2) high systemic activity (HSA), and (3) low systemic activity with high symptoms (LSAHS).
Sacha E Silva‐Saffar, Yann Nguyen, Raphaèle Seror, Jacques‐Eric Gottenberg, Anna Niarakis, Xavier Mariette, Gaetane Nocturne   +6 more
wiley   +1 more source