Results 91 to 100 of about 23,238 (188)

ICOS-expressing CAR-T cells mediate durable eradication of triple-negative breast cancer and metastasis

Journal for ImmunoTherapy of Cancer
Triple-negative breast cancer (TNBC) remains one of the most aggressive and therapeutically challenging breast cancer subtypes. In their recent study, Cao et al introduced a B7H3-specific chimeric antigen receptor (CAR)-T cell with constitutive inducible
Padmanee Sharma, Shelley Herbrich, Mehdi Chaib   +2 more
doaj   +1 more source

Reconstructing the major skull myology of the giant stem‐amphibian Mastodonsaurus: A case study for early tetrapods

Journal of Anatomy, EarlyView.
We reconstruct the major cranial musculature of the giant stem amphibian Mastodonsaurus giganteus, revealing a differentiated jaw‐adductor system, a probable sesamoid pulley, and previously unrecognised muscles. This EPB‐based case study establishes an anatomical framework for modelling feeding in early tetrapods and supports interpretations of ...
Daniel Schwarz, Stephan Lautenschlager, Florian Witzmann, Raphael Moreno, Eudald Mujal, Rainer R. Schoch   +5 more
wiley   +1 more source

A Lived Experience Perspective on Digital Regulatory Practices

Journal of Psychiatric and Mental Health Nursing, EarlyView.
ABSTRACT The paper reflects on a Wellcome‐funded project led by the Medicines and Healthcare products Regulatory Agency (MHRA) in collaboration with the National Institute for Health and Care Excellence (NICE). Initiated in 2023, the project aimed at developing guidance and regulatory frameworks for digital mental health technologies (DMHTs ...
Holly Coole, Grace Gatera, Ellen Thomas
wiley   +1 more source

Antipsychotics‐Induced Hyposalivation Mediated by Impaired Salivary Ca2+ Signaling

Oral Diseases, EarlyView.
ABSTRACT Objectives Antipsychotic‐induced salivary dysfunction such as hyposalivation is a prevalent clinical challenge that severely compromises oral health and quality of life. Although typical and atypical antipsychotics have their therapeutic target in the central nervous system, their direct molecular mechanisms within the salivary glands remain ...
Chaelin Chung, Soohyun Kim, Yoo‐Bin Kim, Hee‐Kyung Park, Se‐Young Choi   +4 more
wiley   +1 more source

Quantifying Dynamic Changes in Stem Storage‐Water Use and Rehydration in Mature Trees: A Study on Pinus sylvestris Trees Exposed to Increased Atmospheric and Soil Drought

Plant, Cell &Environment, EarlyView.
ABSTRACT Forests increasingly experience hot droughts, characterized by rising vapour pressure deficits (VPD) and declining soil moisture, highlighting the need to better understand water fluxes within trees. While stomatal conductance and transpiration are well studied, upstream fluxes such as internal stem water storage use and rehydration dynamics ...
Richard L. Peters, Allan Buras, Simon Armand Grichting, Marcus Schaub, Charlotte Grossiord, Giovanni Bortolami, Jonas Gisler, Volodymyr Trotsiuk, Arthur Gessler, Katrin Meusburger, Stefan Hunziker, Ansgar Kahmen, Andreas Rigling, Lorenz Walthert, Stefan Klesse, Roman Zweifel   +15 more
wiley   +1 more source

The Construction of Compliance with the European Union Deforestation Regulation in Global Coffee Value Chains

Regulation &Governance, EarlyView.
ABSTRACT The European Union's Deforestation Regulation (EUDR) obliges the importers and users of seven agricultural commodities to achieve supply chain traceability and prevent deforestation‐linked products from entering the EU market. This paper investigates how companies and producing countries in the coffee sector prepared for EUDR compliance by ...
Janina Grabs
wiley   +1 more source

Power Unleashed: Theorizing a Weak Ecology of Checks and Balances and Its Consequences. A Case From the Global South

Regulation &Governance, EarlyView.
ABSTRACT This article theorizes about weak checks and balances (C&B) and its plausible consequences. Drawing on empirical data from over 1100 municipal officials in Mexico, the study examines how executive dominance over three key institutions—the local council, internal comptroller offices, and human resources offices—facilitates consequences ...
Oliver Meza, Elizabeth Pérez‐Chiqués, Aldo Martínez‐Hernandez   +2 more
wiley   +1 more source

Dietary amino acid patterns and epilepsy among the PERSIAN cohort population: A cross‐sectional study

Experimental Physiology, EarlyView.
Abstract Epilepsy is characterized by the occurrence of at least two unprovoked seizures occurring more than 24 h apart, reflecting a predisposition to recurrent epileptic events. The role of dietary amino acids (AAs) in epilepsy is not clearly understood. To the best of our knowledge, this study is the first to investigate the link between the odds of
Hamid Abbasi, Ali Jafari, Saeid Doaei, Akram Kooshki, Raul Zamora‐Ros   +4 more
wiley   +1 more source

‘All of It Was Hard. And All of It Was Necessary’: A Reflexive Thematic Analysis of Service User Experience of Group Schema Therapy for Borderline Personality Disorder

Counselling and Psychotherapy Research, Volume 26, Issue 4, December 2026.
ABSTRACT Background Group Schema Therapy is supported by a good evidence base as an effective treatment for Borderline Personality Disorder. Though we are continuing to learn about its mechanisms of change and how it is experienced, published research has not yet explored the experiences of service users in UK Tier 3 mental health services.
Kathleen McGlynn, Emma Smith
wiley   +1 more source

Non-invasive imaging with ICOS-targeting monoclonal antibody for preclinical diagnosis of rheumatoid arthritis in a humanized mouse model

Journal of Translational Medicine
Background Activated T cells play a pivotal role in rheumatoid arthritis (RA) pathogenesis, and imaging of activated T cells may provide a non-invasive tool for RA detection.
Shao Duan, Chao Li, Feng Yan, Yifei Xia, Shuaiming Shao, Weiyu Chen, Zunyu Xiao, Gongping Xu   +7 more
doaj   +1 more source