Results 21 to 30 of about 23,238 (188)
Autoimmunity, 2022 In the current study, we aimed to investigate the effect of paeoniflorin on autoimmune myocarditis. A total of 72 young Lewis rats were randomly divided into control, experimental autoimmune myocarditis (EAM), paeoniflorin low dose (Pae-L 20 mg/kg ...
Chunxiao Wang, Lanlan Wang, Li Wang
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The role of cyclic nucleotide phosphodiesterases in the regulation of adipocyte lipolysis
Journal of Lipid Research, 2005 This study assessed the effects of selective inhibitors of 3′,5′-cyclic nucleotide phosphodiesterases (PDEs) on adipocyte lipolysis. IC224, a selective inhibitor of type 1 phosphodiesterase (PDE1), suppressed lipolysis in murine 3T3-L1 adipocytes (69.6 ±
Peter B. Snyder +4 more
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Human Vaccines & Immunotherapeutics, 2022 Cancer immunotherapy is a powerful tool for inducing antigen-specific antitumor cytotoxic T lymphocytes (CTLs). Next-generation strategies may include vaccination against overexpressed oncogenic tumor-self antigens.
C. Riccay Elizondo +2 more
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ICOS costimulation is indispensable for the differentiation of T follicular regulatory cells
Life Science Alliance, 2023 ICOS signaling promotes T follicular regulatory cell differentiation during germinal center reaction safeguarding against autoantibody production. ICOS is a T-cell costimulatory receptor critical for Tfh cell generation and function. However, the role of
Vincent Panneton +13 more
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RGIFE: a ranked guided iterative feature elimination heuristic for the identification of biomarkers
BMC Bioinformatics, 2017 Background Current -omics technologies are able to sense the state of a biological sample in a very wide variety of ways. Given the high dimensionality that typically characterises these data, relevant knowledge is often hidden and hard to identify ...
Nicola Lazzarini, Jaume Bacardit
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Greenhouse gas observation network design for Africa
Tellus: Series B, Chemical and Physical Meteorology, 2020 An optimal network design was carried out to prioritise the installation or refurbishment of greenhouse gas (GHG) monitoring stations around Africa. The network was optimised to reduce the uncertainty in emissions across three of the most important GHGs:
Alecia Nickless +11 more
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Epigenetics, 2020 CTLA-4 blocking therapeutic antibodies are currently under investigation in head and neck squamous cell carcinoma (HNSCC). A better understanding of the epigenetic regulation of the CD28 superfamily members CD28, CTLA-4, and ICOS and their B7 ligands ...
Luka de Vos +9 more
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Frontiers in Immunology, 2021 BackgroundTh cells (helper T cells) have multiple functions in Schistosoma japonicum (S. japonicum) infection. Inducible co-stimulator (ICOS) is induced and expressed in activated T lymphocytes, which enhances the development of B cells and antibody ...
Shihao Xie +14 more
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Technology Innovation Management Review, 2020 As economies digitalize and many local businesses gradually internationalize, crowdfunding platforms have offered a new way for ventures to raise capital.
Jahja Rrustemi, Nils S. Tuchschmid
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Versioning biological cells for trustworthy cell engineering
Nature Communications, 2022 Full traceability and transparency are important to establish trust in engineered cell lines. Here the authors argue that version control for cell engineering marks a significant step toward more open, reproducible, traceable and ultimately more ...
Jonathan Tellechea-Luzardo +6 more
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