Results 11 to 20 of about 29,154 (297)
ICOS and ICOS ligand: expression patterns and outcomes in oncology patients
Therapeutic Advances in Medical OncologyBackground: Inducible T-cell co-stimulator (ICOS) and its ligand (ICOSL) form a complex, two-faced immune machinery that can lead to both immune stimulation and inhibition.
Mina Nikanjam +8 more
doaj +4 more sources
Role of endocytosis and trans-endocytosis in ICOS costimulator-induced downmodulation of the ICOS Ligand [PDF]
Journal of Leukocyte Biology, 2021 AbstractThe interaction between the T-lymphocyte costimulatory molecule ICOS and its ligand (ICOS-L) is needed for efficient immune responses, but expression levels are tightly controlled, as altered expression of ICOS or ICOS-L may lead to immunodeficiency, or favor autoimmune diseases and tumor growth.Using cells of mouse B cell lymphoma (M12.C3) and
Aragoneses-Fenoll, Laura +8 more
openaire +12 more sources
ICOS-deficient and ICOS YF mutant mice fail to control Toxoplasma gondii infection of the brain.
PLoS ONE, 2020 Resistance to chronic Toxoplasma gondii infection requires ongoing recruitment of T cells to the brain. Thus, the factors that promote, sustain, and regulate the T cell response to the parasite in the brain are of great interest.
Carleigh A O'Brien, Tajie H Harris
doaj +2 more sources
, 2023 This data package contains high accuracy CO2 dry air mole fractions from 58 ICOS and non-ICOS European observatories at in total 132 observation levels, collected by the ICOS Atmosphere Thematic Centre (ATC) and provided by the station contributors.
ICOS Ri,, Lund University.
core +2 more sources
Financial Markets and Portfolio Management, 2019 AbstractWe conduct a detailed analysis of investors in successful initial coin offerings (ICOs). The average ICO has 4700 contributors. The median participant contributes small amounts and many investors sell their tokens before the underlying product is developed.
Rüdiger Fahlenbrach, Marc Frattaroli
openaire +2 more sources
SSRN Electronic Journal, 2020 This chapter sets out to establish the key issues that have become central within the market for Initial Coin Offerings (ICOs). Within this context, we provide a brief overview of the existing literature based on ICOs around the world, while explaining the motivations and styles of criminality that have occurred, the methods that have been widely used ...
Corbet, Shaen, Cumming, Douglas J.
openaire +3 more sources
ICOS costimulation is indispensable for the differentiation of T follicular regulatory cells
Life Science Alliance, 2023 ICOS signaling promotes T follicular regulatory cell differentiation during germinal center reaction safeguarding against autoantibody production. ICOS is a T-cell costimulatory receptor critical for Tfh cell generation and function. However, the role of
Vincent Panneton +13 more
doaj +1 more source
Determinants of ICO success and post-ICO performance
Borsa Istanbul Review, 2023 Initial coin offerings (ICOs) have emerged as an alternative way of raising funds for entrepreneurial ventures to develop a new project or product. In this study, a comprehensive analysis is conducted on the determinants of ICO success and aftermarket performance of ICOs.
Aylin Aslan +2 more
openaire +4 more sources
Autoimmunity, 2022 In the current study, we aimed to investigate the effect of paeoniflorin on autoimmune myocarditis. A total of 72 young Lewis rats were randomly divided into control, experimental autoimmune myocarditis (EAM), paeoniflorin low dose (Pae-L 20 mg/kg ...
Chunxiao Wang, Lanlan Wang, Li Wang
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The role of cyclic nucleotide phosphodiesterases in the regulation of adipocyte lipolysis
Journal of Lipid Research, 2005 This study assessed the effects of selective inhibitors of 3′,5′-cyclic nucleotide phosphodiesterases (PDEs) on adipocyte lipolysis. IC224, a selective inhibitor of type 1 phosphodiesterase (PDE1), suppressed lipolysis in murine 3T3-L1 adipocytes (69.6 ±
Peter B. Snyder +4 more
doaj +1 more source