Results 31 to 40 of about 12,584 (234)

An Investigation of Factors Determining the Token Value in the Blockchain-based Early Funding Mechanism

open access: yesEconomic and Business Review, 2021
The research employs WLS Regression for examining the main determinants of the ICO profitability in the crowdfunding stage. The variables are divided into three main categories: financial and technological aspects, and the ICO characteristics, with the ...
Alfreda Šapkauskienė   +1 more
doaj   +1 more source

Algorithmic populism and the datafication and gamification of the people by Flemish Interest in Belgium

open access: yesTrabalhos em Linguística Aplicada, 2020
Populism studies tend to understand populism as a purely political phenomenon (Mudde; Kaltwasser, 2017; Müller, 2016). To categorize someone as a populist or not, is in many cases solely based on an evaluation of discourse, style or even ideology.
Ico Maly
doaj  

Factors of Success of Initial Coin Offering. Empirical Evidence from 2016–2019

open access: yesФинансы: теория и практика, 2019
Since 2013, Initial Coin Offerings (ICO) have allowed companies to attract financing with the help of cryptocurrencies. Statistics of ICO shows that the ICO market is increasing and demand for funds continues to grow with claims of over $ 15 billion ...
A. S. Myalo, N. Yu. Glukhov
doaj   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

open access: yesAdvanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen   +19 more
wiley   +1 more source

Gut Microbiota, Immunity, and Metabolism in the Progression From Chronic Liver Disease to Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
This review explains how chronic liver injury progresses toward hepatocellular carcinoma through interconnected changes in gut microbes, metabolism, immunity, fibrosis, and diet. It highlights microbial metabolites, bile‐acid signaling, immune dysfunction, and nutritional or microbiome‐based interventions as opportunities to identify risk earlier ...
Yi Hu   +5 more
wiley   +1 more source

Quantum simulation of indefinite causal order induced quantum refrigeration

open access: yesPhysical Review Research, 2022
In the classical world, physical events always happen in a fixed causal order. However, it was recently revealed that quantum mechanics allows events to occur with indefinite causal order (ICO).
Huan Cao   +8 more
doaj   +1 more source

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

open access: yesAdvanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun   +6 more
wiley   +1 more source

Attenuation of Experimental Autoimmune Myositis by Blocking ICOS-ICOS Ligand Interaction [PDF]

open access: yesThe Journal of Immunology, 2007
Abstract Polymyositis (PM) is an acquired, systemic, connective tissue disease characterized by the proximal muscle weakness and infiltration of mononuclear cells into the affected muscles. To understand its etiology and immunopathogenesis, appropriate animal model is required.
Yasuhiro, Katsumata   +9 more
openaire   +2 more sources

Toward Nano‐Nutritional Medicine: A Remotely Activated Trans‐Vaccenic Acid‐Based Lipid Nanoparticles for Enhancing Immune Checkpoint Blockade Therapy

open access: yesAdvanced Science, EarlyView.
Eutectic mixtures from trans‐vaccenic acid (TVA) and stearic acid, which served as phase‐change material to encapsulate IR780, forming NIR‐responsive nanoparticles. IR780@TVA LNPs induce photothermal therapy and initiate adaptive anti‐tumor immunity.
Kang Liu   +12 more
wiley   +1 more source

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