Results 51 to 60 of about 12,584 (234)

Tumor Bushcke Lowenstein de crecimiento nnvertido: a propósito de un caso con propuesta terapéutica

Revista Colombiana de Gastroenterología
El tumor de Buschke-Löwenstein (TBL) es un tipo de tumor epitelial gigante que se caracteriza generalmente por tener una base ancha con potencial infiltrativo y destrucción a nivel local; por tanto, se producen recidivas frecuentemente, lo cual le ...
Juan Ricardo Márquez Velásquez, Luis Francisco Miranda Ruiz, Lina Maria Mateus Barbosa, Sebastían Grisales Ramirez, Carlos Andrés Miranda Ruiz, Jessica Alejandra Tamayo   +5 more
doaj   +1 more source

Multi‐Omic Profiling Reveals Immune Cell Priming Signature Linked to Lupus Prognosis

Arthritis &Rheumatology, EarlyView.
Objective Systemic lupus erythematosus (SLE) is a multiorgan disease with widespread immune dysregulation and significant unmet clinical need. Blood‐based gene expression studies have advanced our understanding of SLE pathogenesis but may overlook critical tissue‐specific mechanisms that drive disease heterogeneity and progression.
Michael A. Smith, Dominic Sinibaldi, Saifur Rahman, Chia‐Chien Chiang, Anna M. Hansen, Jill Henault, Carlos P. Roca, Shu Wang, Kamelia Zerrouki, Rebecca Filippi, Christopher Groves, Zerai Manna, Jun Chu, Michael Davis, Sarthak Gupta, Christopher Morehouse, Melissa de los Reyes, Rachel Ettinger, Roland Kolbeck, Mariana J. Kaplan, Miguel A. Sanjuan, Richard M. Siegel, Sarfaraz A. Hasni, Kerry A. Casey   +23 more
wiley   +1 more source

Single‐Cell Level Characterization of B Cell Depletion and Repopulation Following Rituximab in Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective Rituximab, a CD20+ B cell depletion therapy, is frequently used to treat systemic lupus erythematosus (SLE). However, variability in patient response highlights the need for a deeper understanding of the underlying immune cell dynamics of B cell depletion and repopulation.
Haerin Jang, Norzawani Buang, Catherine Sutherland, Wanseon Lee, Lauren Overend, Tarran S. Rupall, Katie L. Burnham, Matthew C. Pickering, Marina Botto, Emma E. Davenport   +9 more
wiley   +1 more source

A novel tropically stable oral amphotericin B formulation (iCo-010) exhibits efficacy against visceral Leishmaniasis in a murine model. [PDF]

PLoS Neglected Tropical Diseases, 2010
To develop an oral formulation of amphotericin B (AmB) that is stable at the temperatures of WHO Climatic Zones 3 and 4 (30-43 °C) and to evaluate its efficacy in a murine model of visceral leishmaniasis (VL).The stability testing of four novel oral ...
Ellen K Wasan, Pavel Gershkovich, Jinying Zhao, Xiaohua Zhu, Karl Werbovetz, Richard R Tidwell, John G Clement, Sheila J Thornton, Kishor M Wasan   +8 more
doaj   +1 more source

Aberrant Neural Entrainment to Word‐Level Speech Patterns in Fragile X Syndrome: Evidence for a Statistical Learning Deficit

Autism Research, EarlyView.
ABSTRACT Fragile X syndrome (FXS), the most common inherited cause of intellectual disability and autism spectrum disorder, causes significant language and cognitive impairments. Statistical learning refers to the ability to extract patterns from sensory input through mere exposure and plays a central role in language acquisition.
Laura J. Batterink, Yanchen Liu, Grace Westerkamp, Jae Citarella, Peyton Siekierski, Lynxie Voorhees, Lauren E. Ethridge, Elizabeth Smith, Rana Elmaghraby, Craig A. Erickson, Zag ElSayed, Anubhuti Goel, Steve W. Wu, Ernest V. Pedapati   +13 more
wiley   +1 more source

The interplay between molecular architecture, pharmacology, and suspected adverse drug reactions associated with nonsteroidal androgen antagonists in the United Kingdom

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to correlate potential links between the suspected adverse drug reaction (ADR) profile of licensed nonsteroidal androgen receptor antagonists (NSARA) with their unique chemical properties and known off‐target polypharmacology. Methods Physicochemical and polypharmacology data were curated from the Electronic Medicines Compendium ...
Simrit Dhillon, Albert A. Antolin, Alan M. Jones   +2 more
wiley   +1 more source

CLINICAL AND SURVIVAL IMPACT OF FDG PET IN PATIENTS WITH SUSPICION OF RECURRENT OVARIAN CANCER: A 6-YEAR FOLLOW-UP

Frontiers in Medicine, 2015
Background: The aim of this retrospective study was to evaluate the contribution of FDG PET to the clinical management and survival outcome of patients (pts) suspected of recurrent ovarian carcinoma, with the hypothesis that early diagnosis of recurrent ...
Daniela eRusu, Thomas eCarlier, Thomas eCarlier, Mathilde eColombié, Dorothée eGoulon, Vincent eFleury, Nicolas eRousseau, Dominique eBerton-Rigaud, Isabelle eJaffre, Françoise eKraeber-Bodéré, Françoise eKraeber-Bodéré, Loic eCampion, Loic eCampion, Caroline eRousseau, Caroline eRousseau   +14 more
doaj   +1 more source

ICOS and ICOS ligand: expression patterns and outcomes in oncology patients

Therapeutic Advances in Medical Oncology
Background: Inducible T-cell co-stimulator (ICOS) and its ligand (ICOSL) form a complex, two-faced immune machinery that can lead to both immune stimulation and inhibition. Objective: We explored ICOS transcriptomic expression patterns
Mina Nikanjam, Shumei Kato, Daisuke Nishizaki, Donald A. Barkauskas, Sarabjot Pabla, Mary K. Nesline, Jeffrey M. Conroy, Aung Naing, Razelle Kurzrock   +8 more
openaire   +3 more sources

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

The EPICURE study: a pilot prospective cohort study of heterogeneous and massive data integration in metastatic breast cancer patients

BMC Cancer, 2021
Background Breast cancer is the most common cancer in women and the first cancer concerning mortality. Metastatic breast cancer remains a disease with a poor prognosis and about 30% of women diagnosed with an early stage will have a secondary progression.
Mathilde Colombié, Pascal Jézéquel, Mathieu Rubeaux, Jean-Sébastien Frenel, Frédéric Bigot, Valérie Seegers, Mario Campone   +6 more
doaj   +1 more source