Results 111 to 120 of about 117,111 (323)

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Locally preferred structure in simple atomic liquids

, 2003
We propose a method to determine the locally preferred structure of model liquids. This latter is obtained numerically as the global minimum of the effective energy surface of clusters formed by small numbers of particles embedded in a liquid-like ...
G. Tarjus, S. Mossa, Yonezawa F.
core   +1 more source

ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models

PLoS ONE, 2020
Immunotherapy checkpoint inhibitors, such as antibodies targeting PD-1 and CTLA-4, have demonstrated the potential of harnessing the immune system to treat cancer.
A. Hanson, Kutlu G. Elpek, Ellen Duong, Lindsey A. Shallberg, M. Fan, Calvin Johnson, Matt Wallace, G. R. Mabry, Stephen Sazinsky, L. Pepper, C. Shu, S. Sathyanarayanan, Sarah Zuerndorfer, T. Simpson, M. Gostissa, M. Briskin, Deborah A. Law, J. Michaelson, Christopher J Harvey   +18 more
semanticscholar   +1 more source

A Glucose‐Responsive Intelligent Antibacterial and Oxygen‐Producing Hydrogel Promotes the Healing of Diabetic Wounds by Regulating Cellular Heterogeneity

Advanced Science, EarlyView.
We have developed a glucose‐triggered on‐demand drug delivery CF‐CPGaMPN hydrogel based on borate ester bonds. It inactivates microbes, releases oxygen, and enables on‐demand drug release in high‐glucose environments to promote healing of diabetic wounds. Single‐cell sequencing reveals that the CF‐CPGaMPN hydrogel significantly alleviates dysfunctional
Manxuan Liu, Zhongcheng Li, Qian Ren, Ziqian Lu, Yubing Zhang, Yili Guo, Ruomeng Li, Die Hu, Linglin Zhang   +8 more
wiley   +1 more source

Using media to improve the informed consent process for youth undergoing pediatric endoscopy and their parents. [PDF]

, 2017
Background and study aims Youth undergoing pediatric endoscopic procedures and their parents demonstrate suboptimal comprehension of the informed consent (IC) process.
Chun, Stanford, Huang, Jeannie S, Terrones, Laura, Yeh, Debra M   +3 more
core   +1 more source

An Antibody Targeting ICOS Increases Intratumoral Cytotoxic to Regulatory T-cell Ratio and Induces Tumor Regression

Cancer immunology research, 2020
T-regulatory cells (Treg) can inhibit the efficacy of immune checkpoint blockade in cancer. Depleting Tregs with an ICOS-specific antibody increases the function of T effector cells, delays tumor growth, and improves immune checkpoint blockade efficacy ...
R. Sainson, A. Thotakura, M. Kosmač, Gwenoline Borhis, Nahida Parveen, R. Kimber, J. Carvalho, Simon J. Henderson, Kerstin Pryke, Tracey Okell, Siobhan O'Leary, Stuart Ball, C. Van Krinks, L. Gamand, Emma Taggart, E. Pring, Hanif Ali, H. Craig, V. Wong, Qi Liang, R. Rowlands, M. Lecointre, J. Campbell, I. Kirby, D. Melvin, V. Germaschewski, E. Oelmann, S. Quaratino, M. Mccourt   +28 more
semanticscholar   +1 more source

Nanoparticle Immunoadjuvant Complexes Augment Germinal Center Responses to Vaccination

Advanced Science, EarlyView.
Scaffolding IL‐21 on the surface of a self‐assembling nanoparticle immunogen drives improved germinal center and humoral immune responses. These nanoparticle immunoadjuvant complexes (NICs) functionally modulate the germinal center driving improved somatic hypermutation and antibody maturation, suggesting this platform has potential utility as a ...
Nicholas J. Tursi, Colby J. Agostino, Jinwei Huang, Toshitha Kannan, Niklas Laenger, Jennifer Londregan, Katlyn Lederer, Michaela Helble, Nicole Bedanova, Cory Livingston, Ebony N. Gary, Madison McCanna, Marta Tarquis Medina, Rumi Habib, Ignacio Rodriguez Relaño, Ivan Maillard, Ami Patel, David Allman, Andrew Kossenkov, Amelia Escolano, Daniel W. Kulp, David. B. Weiner   +21 more
wiley   +1 more source

Inducible Costimulator Expressing T Cells Promote Parasitic Growth During Blood Stage Plasmodium berghei ANKA Infection

Frontiers in Immunology, 2018
The lethality of blood stage Plasmodium berghei ANKA (PbA) infection is associated with the expression of T-bet and production of cytokine IFN-γ. Expression of inducible costimulator (ICOS) and its downstream signaling has been shown to play a critical ...
Gajendra M. Jogdand, Soumya Sengupta, Gargee Bhattacharya, Santosh Kumar Singh, Prakash Kumar Barik, Satish Devadas   +5 more
doaj   +1 more source

Ocular Involvement of Relapsed Nodal T Follicular Helper Cell Lymphoma, Angioimmunoblastic Type. [PDF]

EJHaem
eJHaem, Volume 7, Issue 1, February 2026.
Bamba S, Nishikubo M, Ito SI, Yamakawa J, Hara S, Yamamoto R.   +5 more
europepmc   +2 more sources

Gemini/GMOS Spectroscopy of EXO 0748-676 (=UY Vol) in Outburst [PDF]

, 2012
We present a phase-resolved, optical, spectroscopic study of the eclipsing low-mass X-ray binary, EXO 0748-676 = UY Vol. The sensitivity of Gemini combined with our complete phase coverage makes for the most detailed blue spectroscopic study of this ...
Hynes, Robert I., Mikles, Valerie J.
core   +3 more sources