Results 131 to 140 of about 136,329 (313)

Synchrotron XRF Imaging Reveals Manganese Accumulation in the Golgi and Post‐Synapses of Neurons and Enhanced Uptake in Astrocytes

open access: yesAdvanced Science, EarlyView.
Despite widespread exposure, the mechanisms of manganese neurotoxicity remain poorly understood. Using correlative cryogenic fluorescence and synchrotron X‐ray fluorescence imaging techniques, we show that the Golgi apparatus is the primary accumulation site for manganese in both neurons and astrocytes, and that manganese targets the neuronal ...
Ines Kelkoul   +12 more
wiley   +1 more source

Position of Ice Divides and Ice Centers on Ice Sheets

open access: yesJournal of Glaciology, 1973
Model calculations are made of the magnitude of the shift of the portion of an ice divide on a two dimensional ice sheet and of the “center” (the position of highest elevation) of a circular ice sheet when the rate of accumulation is different on different sides or in different sectors of an ice sheet.
openaire   +1 more source

Big Questions at ICS with Grace Carhart Pt. 1: Wonder

open access: yes, 2019
Do you ever wonder? This is the first in a short series of Critical Faith episodes based on guiding worldview questions. ICS Junior Member Grace Carhart has conducted a series of interviews of ICS Senior Members, asking them to reflect on the themes of ...
Kuipers, Ronald   +5 more
core  

Participation in volunteer work 1993

open access: yes, 2007
Participation in volunteer work Leisure activities: sport, watching tv, radio, music, party games, hobbies: individual, in club, with friends / visits to-from family, circle of acquaintances / satisfaction with amount of leisure time / knowledge of ...
Lindeman, E.M., Rijksuniversiteit Utrecht * Utrecht, Interuniversitair centrum theorievorming en methodenontwikkeling sociologie, ICS * Utrecht (primary investigator)
core   +1 more source

Corals and Reef‐Dwelling Fish Regulate Carbon Storage and Cycling Processes in Coral Reef Ecosystems

open access: yesAdvanced Science, EarlyView.
Coral reefs are biodiversity hotspots, yet their role in carbon storage and cycling remains poorly understood. Using field surveys and modeling in the South China Sea, we reveal the overlooked potential of carbon storage in reef ecosystems and how reef fish, corals, and surface sediment jointly shape reef carbon reservoirs.
Yiting Chen   +8 more
wiley   +1 more source

Evolución de la gestación en una mujer afecta de TLP

open access: yesPsicosomática y Psiquiatría, 2021
A. Murillo Monterroso   +4 more
doaj   +1 more source

Human Responses to Art: Good, Bad, and Indifferent

open access: yes, 1983
oai:https://ir.icscanada.edu:10756/313405This book chapter was also distributed by the Institute for Christian Studies (with permission) in 1984 as: ICS Academic Papers; September ...
Seerveld, Calvin
core  

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

open access: yesAdvanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu   +10 more
wiley   +1 more source

Selective Targeting of Immune Checkpoints HLA‐G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

open access: yesAdvanced Science, EarlyView.
The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob   +12 more
wiley   +1 more source

Gene-environment interaction analysis of school quality and educational inequality

open access: yesnpj Science of Learning
We study to what extent schools increase or decrease environmental and genetic influences on educational performance. Building on behavioral genetics literature on gene-environment interactions and sociological literature on the compensating and ...
Kim Stienstra   +2 more
doaj   +1 more source

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