Results 141 to 150 of about 136,329 (313)

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

Big Questions at ICS with Grace Carhart Pt. III: Hope

, 2019
Is hope dangerous? This is the third in a short series of Critical Faith episodes based on thinking through some of life's big questions. ICS Junior Member Grace Carhart has conducted a series of interviews with ICS Senior Members Nik Ansell, Ronald A ...
Ansell, Nik, Kuipers, Ronald, Carhart, Grace, Sweetman, Robert, Smick, Rebekah, Yett, Danielle   +5 more
core  

ICS-SUFU standard: Theory, terms, and recommendations for pressure-flow studies performance, analysis, and reporting, Part 1: Background theory and practice

, 2023
Aims: The working group (WG) initiated by the International Continence Society Standardization Steering Committee and supported by the Society of Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction has revised the (1997) ICS Standard for ...
The Members of the ICS Working Group PFS23
core  

Metabolic Imbalance Triggers Adaptive Remodeling to Accelerate Diploidization in Murine Haploid Embryonic Stem Cells

Advanced Science, EarlyView.
In this article, Shuai and colleagues demonstrate that metabolic remodeling drives self‐diploidization in murine haploid ESCs (haESCs). Mitochondrial dysfunction and imbalanced pyruvate metabolism underlie this process. Genome‐wide screening using haESCs identifies key mitochondrial quality‐control related genes, enabling a metabolism‐based medium that
Yi Fu, Wenhao Zhang, Yifan Zhang, Yu He, Yi Du, Yiding Zhao, Chunmeng Yao, Shengyi Sun, Xiaoyan Sheng, Qian Gao, Chao Tong, Ling Shuai   +11 more
wiley   +1 more source

Big Questions at ICS with Grace Carhart Pt. II: Heartbreak

, 2019
How do we live with heartbreak--and live well? This is the second in a short series of Critical Faith episodes based on guiding worldview questions. ICS Junior Member Grace Carhart has conducted a series of interviews with ICS Senior Members Nik Ansell ...
Ansell, Nik, Kuipers, Ronald, Carhart, Grace, Sweetman, Robert, Smick, Rebekah, Yett, Danielle   +5 more
core  

Power, performance and area prediction of 3D ICs during early stage design exploration in 45nm

, 2011
In this work, the impact of across-chip temperature and power supply voltage variations, on performance predictions in 3D ICs, is investigated. To make this possible, a novel design flow is proposed to perform design exploration of 3D ICs.
Antonis Papanikolaou, Stamoulis, G, Toufexis, F., Papanikolaou, A, Soudris, D, Bantas, S., Bantas, S, Papanikolaou, A., Stamoulis, G., Sotiris Bantas, George Stamoulis, Toufexis, F, Dimitrios Soudris, Soudris, D., Filippos Toufexis   +14 more
core   +1 more source

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

Interethnic Contacts: A Dynamic Analysis of Interaction between Immigrants and Natives in Western Countries.

, 2010
Thesis University Utrecht ICS The full text of this item will be available after 10-09 ...
Martinovic, Borja,, Solidarity 2000+ (ICS), Afd sociologie, Martinovic, B., Social Networks, Solidarity and Inequality, Martinovic, Borja   +5 more
core  

Oral Motion‐Powered Smart Dental Implant Abutment for In Situ Antibacterial and Cell Adhesion Through Piezoelectric Effect

Advanced Science, EarlyView.
We proposed a method based on the piezoelectric effect and fabricated an implant abutment on the basis of piezoelectric ceramic. Under physiological occlusal pressure, the oral motion‐powered smart dental implant abutments interacted with water and oxygen, promoting the formation of reactive oxygen species and achieving a synergistic and highly ...
Xiyu Shi, Xiaoyu Han, Yanhui Lu, Yuan Chai, Baiyan Xiao, Shuo Liu, Boon Chin Heng, Tingting Wu, Tingjun Li, Qiaomei Ren, Ting Song, Le Chen, Dong Han, Yaru Guo, Xuliang Deng, Xuehui Zhang   +15 more
wiley   +1 more source

Grupo de soporte a la inferitlidad

Psicosomática y Psiquiatría, 2021
G Labay Rodriguez, C San Benito, A Zaragoza   +2 more
doaj   +1 more source