Results 141 to 150 of about 20,996 (348)

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Diabetes mellitus y riesgo de ictus

, 2012
Objetivos: Revisar las evidencias disponibles que relacionan la diabetes mellitus con el riesgo de ocurrencia del ictus y el papel del control de la glicemia mediante diversas estrategias en la disminución del riesgo de ictus.
Buergo Zuaznábar, Miguel Angel, López Jiménez, Melvin, Fernández Concepción, Otman   +2 more
core  

Ictus: Prevención primaria, secundaria y terciaria

El ictus es una enfermedad cardiovascular sobre la que se puede realizar una prevención primaria, secundaria y terciaria. En este caso la prevención primaria consiste en prevenir la aparición del ictus, en la prevención secundaria se reduce el riesgo de ...
Blasco-Abadía, Julia, Buesa-Estéllez, Almudena, Medina Rincón, Almudena, López-Royo, María Pilar, de Diego-Alonso, Cristina, Roldán Pérez, Patricia, Doménech-García, Víctor, Bellosta-López, Pablo, Giner Nicolás, Rafael   +8 more
core   +1 more source

Ictus

, 2017
L'ictus és la primera causa de discapacitat greu en l'adult -tant física com intel·lectual- i de dependència i la segona causa de mort a Espanya, segons dades de l'Observatori del Ictus, que preveu un gran impacte demogràfic, sanitari i social d'aquest problema de salut en les properes dècades.
openaire   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

Ictus cardioembólico

Anales del Sistema Sanitario de Navarra
Este artículo no tiene ...
Irimia, P., Lázaro, D., Zubiri, F., Martínez-Vila, E.   +3 more
openaire   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Encefalopatía por contraste secundaria a posible daño endotelial tras trombectomía mecánica exitosa

Neurología, 2020
C. Aguirre, S. Trillo, Á. Ximénez-Carrillo, J. Vivancos   +3 more
doaj   +1 more source