Results 91 to 100 of about 981,530 (240)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Nucleic Acids Res., 2014 CFM-ID is a web server supporting three tasks associated with the interpretation of tandem mass spectra (MS/MS) for the purpose of automated metabolite identification: annotation of the peaks in a spectrum for a known chemical structure; prediction of ...
Felicity Allen +4 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Examining the Relationship between Psychosocial Work Factors and Musculoskeletal Discomfort among Computer Users in Malaysia [PDF]
Iranian Journal of Public Health, 2011 "nBackground: With computers rapidly carving a niche in virtually every nook and crevice of today's fast-paced society, mus­culoskeletal disorders are becoming more prevalent among computer users, which comprise a wide spectrum of the ...
SA Zakerian, ID Subramaniam
doaj +2 more sources
Comparative Psychoanalytic Study Of Poe’s “the Oval Portrait” And Hawthorne’s “the Birthmark”
The Journal of Studies in Language, Culture and SocietyThe present study discusses Psychological concepts such as id, Eros, obsession, narcissism, and aggression as they are represented in Hawthorne’s “The Birthmark” (1843) and Poe’s “The Oval Portrait” (1842).
Hejazi Bayan
doaj
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Disruptive de novo mutations of DYRK1A lead to a syndromic form of autism and ID
Molecular Psychiatry, 2015 Dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1 A (DYRK1A) maps to the Down syndrome critical region; copy number increase of this gene is thought to have a major role in the neurocognitive deficits associated with Trisomy 21. Truncation
B. V. van Bon +21 more
semanticscholar +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Aquatic Biology, 2014 Apristurus is a genus of typically small sharks that inhabit deep waters around the globe. Relatively little is known about the feeding behaviour of these species. Here, the electrosensory biology of 3 species, A. aphyodes, A. melanoasper and A. microps,
DM Moore, ID McCarthy
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source