Results 81 to 90 of about 981,530 (240)

CaMKII-mediated Beclin 1 phosphorylation regulates autophagy that promotes degradation of Id and neuroblastoma cell differentiation

Nature Communications, 2017
Autophagy is a degradative pathway that delivers cellular components to the lysosome for degradation. The role of autophagy in cell differentiation is poorly understood. Here we show that CaMKII can directly phosphorylate Beclin 1 at Ser90 to promote K63-
Xuan Li, Xiao-Qi Wu, R. Deng, Dan-dan Li, Jun Tang, Wen-dan Chen, Jing-Hong Chen, Jiao Ji, Lin Jiao, Shan Jiang, Fen Yang, G. Feng, R. Senthilkumar, F. Yue, Hai-Liang Zhang, Ruiyan Wu, Yan Yu, Xue-lian Xu, J. Mai, Zhi-Ling Li, Xiao-dan Peng, Yun Huang, Xiang Huang, Ning Ma, Q. Tao, Yi-Xin Zeng, Xiao-feng Zhu   +26 more
semanticscholar   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Classification System for Soil Types Suitable for Food Crops using Naïve Bayes Method

Sistemasi: Jurnal Sistem Informasi
Agriculture in Indonesia, especially in Aceh, plays a central role in supporting the economy and food security. The success of agriculture is greatly influenced by the selection of appropriate soil types.
Nurdin S.Kom., M.Kom (SCOPUS ID=ID: 57201646662)
doaj   +1 more source

Semantic frame induction through the detection of communities of verbs and their arguments

Applied Network Science, 2020
Resources such as FrameNet, which provide sets of semantic frame definitions and annotated textual data that maps into the evoked frames, are important for several NLP tasks.
Eugénio Ribeiro, Andreia Sofia Teixeira, Ricardo Ribeiro, David Martins de Matos   +3 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Investigation of Moral Hazard Deportments in Community-Based Health Insurance in Guto Gida District, Western Ethiopia: A Qualitative Study

ClinicoEconomics and Outcomes Research, 2020
Isubalew Daba Ayana Department of Economics, Wollega University, Nekemte, EthiopiaCorrespondence: Isubalew Daba AyanaDepartment of Economics, Wollega University, Nekemte, EthiopiaEmail isubalewmsc@gmail.comIntroduction: Ethiopia introduced CBHI in 2011 ...
Ayana ID
doaj  

Analysis of pressure variation of fluid in bounded circular reservoirs under the “No Flow” outer boundary condition

Journal of Applied Sciences and Environmental Management, 2017
Predicting the pressure at the wellbore in bounded circular reservoir has been the hub in the study of Reservoir Engineering. Predicting the pressures outside the reservoir was not an easy task.
ID Erhunmwun, JA Akpobi
doaj   +1 more source

FLOR-ID: an interactive database of flowering-time gene networks in Arabidopsis thaliana

Nucleic Acids Res., 2015
Flowering is a hot topic in Plant Biology and important progress has been made in Arabidopsis thaliana toward unraveling the genetic networks involved. The increasing complexity and the explosion of literature however require development of new tools for
F. Bouché, G. Lobet, P. Tocquin, C. Périlleux   +3 more
semanticscholar   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source