Results 61 to 70 of about 10,890,628 (275)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
THE MEANING OF ACOSMIA IN ARISTOTLE, POLITICS II, 1272b1-16
Síntesis. Revista de Filosofía, 2018 The Greek word acosmia, in opposition to cosmos, refers to disorder and bad behavior, on a physical, moral or social level. In the Politics of Aristotle II, 1272b1-16, the word acosmia is used in the description of Cretan institutions. In this particular
Amarande Laffon
doaj +1 more source
Authentication System based on ID-Network Smart Cards (ID-NSCards) for Critical Environments [PDF]
, 2008 Researchers in the Information Security area in the Carlos III University of Madrid (Spain) are interested to exploit the potential of an emerging technology: network smart cards.
Sierra Cámara, José María
core +1 more source
Screening for Infectious diseases among newly arrived migrants. experiences and practices in non-EU countries of the Mediterranean basin and Black Sea [PDF]
, 2015 Changing migration dynamics in the Mediterranean Sea and differences in infectious diseases (ID) burden between the countries of origin have raised questions whether public health actions are needed to avoid the transmission of ID.
Christian Napoli +6 more
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
IDGenerator: unique identifier generator for epidemiologic or clinical studies
BMC Medical Research Methodology, 2016 Background Creating study identifiers and assigning them to study participants is an important feature in epidemiologic studies, ensuring the consistency and privacy of the study data.
Matthias Olden +3 more
doaj +1 more source
Scientific Reports, 2023 Given the inherent complexity of the human nervous system, insight into the dynamics of brain activity can be gained from studying smaller and simpler organisms.
Ruxandra Barbulescu +3 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source