Results 51 to 60 of about 12,634,313 (292)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Legal Protection of Smart Water Technologies: The Role of Patents in Promoting Innovation [PDF]
E3S Web of ConferencesWater-related issues are becoming more pressing on the backdrop of climate change, growing population increase, as well as increasing urban demand.
Id Said Abelkarim
doaj +1 more source
Semantic frame induction through the detection of communities of verbs and their arguments
Applied Network Science, 2020 Resources such as FrameNet, which provide sets of semantic frame definitions and annotated textual data that maps into the evoked frames, are important for several NLP tasks.
Eugénio Ribeiro +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
SHAPE-ID Toolkit Resources - Develop a Career in Inter- or Transdisciplinary Research
, 2021 Early-stage researchers, in particular, can receive very mixed messages about the wisdom of pursuing an inter- or transdisciplinary research career which is often regarded as high risk within a research system that is still primarily structured on ...
SHAPE-ID
core +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
THE MEANING OF ACOSMIA IN ARISTOTLE, POLITICS II, 1272b1-16
Síntesis. Revista de Filosofía, 2018 The Greek word acosmia, in opposition to cosmos, refers to disorder and bad behavior, on a physical, moral or social level. In the Politics of Aristotle II, 1272b1-16, the word acosmia is used in the description of Cretan institutions. In this particular
Amarande Laffon
doaj +1 more source
Molecular Oncology, EarlyView.Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both +7 more
wiley +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source