Results 71 to 80 of about 6,962,642 (291)
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
, 2012 This annual report presents the research activities and achievements of INESC-ID, a Portuguese research institute focused on advanced research and development in Electronics, Communications, and Information Technologies.
Aurélia Constantino
core
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
, 2010 This report presents an overview of INESC-ID's research activities and achievements in 2010, highlighting its focus on advanced research and development in electronics, communications, and information technologies.
Aurélia Constantino
core
Examining the Relationship between Psychosocial Work Factors and Musculoskeletal Discomfort among Computer Users in Malaysia [PDF]
Iranian Journal of Public Health, 2011 "nBackground: With computers rapidly carving a niche in virtually every nook and crevice of today's fast-paced society, mus­culoskeletal disorders are becoming more prevalent among computer users, which comprise a wide spectrum of the ...
SA Zakerian, ID Subramaniam
doaj +2 more sources
ClinicoEconomics and Outcomes Research, 2020 Isubalew Daba Ayana Department of Economics, Wollega University, Nekemte, EthiopiaCorrespondence: Isubalew Daba AyanaDepartment of Economics, Wollega University, Nekemte, EthiopiaEmail isubalewmsc@gmail.comIntroduction: Ethiopia introduced CBHI in 2011 ...
Ayana ID
doaj
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Technical Annex to the contract of INESC-ID Laboratório Associado.
, 2011 This technical annex outlines the research and development objectives of INESC-ID Laboratório Associado, focusing on four strategic areas: Systems Interactivos Inteligentes, Sistemas de Informação e Suporte à Decisão, Sistemas Computacionais e Redes de ...
Leonel Sousa
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source