Results 91 to 100 of about 5,124 (246)

CDR L3 Loop Rearrangement Switches Multispecific SPE‐7 IgE Antibody From Hapten to Protein Binding

Journal of Molecular Recognition, Volume 37, Issue 6, November 2024.
ABSTRACT The monoclonal IgE antibody SPE‐7 was originally raised against a 2,4‐dinitrophenyl (DNP) target. Through its ability to adopt multiple conformations, the antibody is capable of binding to a diverse range of small haptens and large proteins.
Clarissa A. Seidler, Klaus R. Liedl
wiley   +1 more source

Design of small-molecule active-site inhibitors of the S1A family proteases as procoagulant and anticoagulant drugs [PDF]

, 2017
Vitamin K antagonists (VKA) have long been the default drugs for anticoagulant management in venous thrombosis. While efficacious, they are difficult to use due to interpatient dose–response variability and the risks of bleeding.
Banner D. W., Bode W., Budovich A., Cool D. E., Fritz H., Giansily-Blaizot M., Himber J., Mather T., Peter M. Fischer, Sun W. Y.   +9 more
core   +2 more sources

Reversal of Dabigatran with Idarucizumab in Acute Subarachnoid Hemorrhage

Clinical Practice and Cases in Emergency Medicine, 2017
Dabigatran etexilate mesylate is a direct thrombin inhibitor used for reducing the risk of stroke and systemic embolism in patients with non-valvular atrial fibrillation.
Jonathan Balakumar, Ruben Santiago, Mark Supino   +2 more
doaj   +1 more source

Asia-Pacific working group consensus on non-variceal upper gastrointestinal bleeding: An update 2018 [PDF]

, 2018
Non-variceal upper gastrointestinal bleeding remains an important emergency condition, leading to significant morbidity and mortality. As endoscopic therapy is the 'gold standard' of management, treatment of these patients can be considered in three ...
Bjorkman, D.J. (David J.), Chan, F.K.L. (Francis K.L.), Chiu, P.C.Y. (Philip C.Y.), Goh, K.-L. (Khean-Lee), Gotoda, T. (Takuji), Ho, L.H.Y. (Lawrence H.Y.), Jensen, D.M. (Dennis), Jung, H.-Y. (Hwoon-Young), Kuipers, E.J. (Ernst J.), Lanas, A. (Angel), Lau, J.Y.W. (James), Reddy, N. (N.), Singh, R. (Rajvinder), Sollano, J. (José), Sugano, K. (Kentaro), Sung, J.J.Y. (Joseph), Wu, C.-Y. (Chun-Yin), Wu, K.-C. (Kai-Chun)   +17 more
core   +5 more sources

Anticoagulation and Antiplatelet Regimen in Cardiac Transplant. Clinical Characteristics, Outcomes, and Blood Product Transfusion

Clinical Transplantation, Volume 38, Issue 7, July 2024.
ABSTRACT Background We aimed to evaluate the characteristics, clinical outcomes, and blood product transfusion (BPT) rates of patients undergoing cardiac transplant (CT) while receiving uninterrupted anticoagulation and antiplatelet therapy. Methods A retrospective, single‐center, and observational study of adult patients who underwent CT was performed.
Maria del Val Groba Marco, Pedro Saavedra Santana, Luz Maria Gonzalez del Castillo, Mario Galvan Ruiz, Miguel de Fernandez de Sanmamed, Stefano Urso, Elisabet Guerra Hernández, Laura Quintana Paris, Michelle Tout Castellano, Jose Luis Romero Lujan, Eduardo Jose Caballero Dorta, Luisa Maria Guerra Dominguez, Antonio Garcia Quintana   +12 more
wiley   +1 more source

Anticoagulantes orais diretos, antídotos e possíveis interações [PDF]

, 2016
Monografia realizada no âmbito da unidade de Estágio Curricular do Mestrado Integrado em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de CoimbraA terapêutica anticoagulante foi, durante um longo período e até há pouco tempo,
Graça, João Pedro Antunes
core  

State of play and future direction with NOACs: An expert consensus. [PDF]

, 2018
Atrial fibrillation (AF) and venous thromboembolism (VTE) are cardiovascular conditions significant in contemporary practice. In both, the use of anticoagulation with vitamin K antagonists (VKAs) has been traditionally used to prevent adverse events ...
A.J. Camm, A.T. Cohen, Ageno, Agnelli, Alings, Ansell, Ansell, Apostolakis, Avgil-Tsadok, Beyer-Westendorf, Beyer-Westendorf, Beyer-Westendorf, Bohula, Bouillon, Brunner-Ziegler, Caldeira, Caldeira, Camm, Cannon, Cohen, Cohen, Coleman, Connolly, Connolly, Connolly, Cronin-Fenton, De Caterina, De Caterina, De Caterina, De Caterina, Diener, Diener, Diener, Douketis, Easton, Eikelboom, Ensor, F. Verheugt, Fang, Fauchier, Forslund, Fox, Friberg, Friberg, Furugohri, G. Agnelli, G.Y. Lip, Gage, Gibson, Giugliano, Glund, Granger, Gross, Guo, H. Heidbuchel, Hankey, Heidbuchel, Heidbuchel, Heit, Heit, Hijazi, Hohnloser, Husted, Investigators, J.L. Zamorano, Kearon, Keeling, Khorana, Kirchhof, Kooiman, Kooistra, Larsen, Levy, Lip, Lip, Lip, Lip, Lip, Lublóy, Martinez, Masjuan, Mendell, Mendell, Miyasaka, Moore, Morgan, Mungall, Murphy, Márquez-Contreras, Nielsen, Oldgren, Paciaroni, Paciaroni, Patel, Perzborn, Peterson, Pinto, Pollack, Pollack, Price, Prins, Proietti, Proietti, R. De Caterina, Raskob, Renda, Roffi, Roldán, Ruff, Ruff, Sandén, Sardar, Sardar, Sarich, Schulman, Schulman, Senoo, Senoo, Shekelle, Sjögren, Song, Stacy, Stampfuss, Stangier, Steinberg, Tafur, The EINSTEIN investigators, The EINSTEIN–PE Investigators, van der Hulle, van Walraven, Verhamme, Vrijens, Watanabe, Weitz, Wolf, Zamorano   +135 more
core   +5 more sources

Chinese guidelines for the diagnosis and management of atrial fibrillation

Pacing and Clinical Electrophysiology, Volume 47, Issue 6, Page 714-770, June 2024.
Abstract Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, significantly impacting patients' quality of life and increasing the risk of death, stroke, heart failure, and dementia. Over the past two decades, there have been significant breakthroughs in AF risk prediction and screening, stroke prevention, rhythm control, catheter ...
Changsheng Ma, Shulin Wu, Shaowen Liu, Yaling Han   +3 more
wiley   +1 more source

Successful intravenous thrombolysis for ischemic stroke after reversal of dabigatran anticoagulation with idarucizumab: a case report

Journal of Medical Case Reports, 2017
Background Non-vitamin K antagonist oral anticoagulants, including dabigatran, are currently widely used for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation.
Sergio Agosti, Laura Casalino, Enrico Rocci, Gabriele Zaccone, Eugenia Rota   +4 more
doaj   +1 more source

Outcome of intracerebral hemorrhage associated with different oral anticoagulants [PDF]

, 2017
Objective: In an international collaborative multicenter pooled analysis, we compared mortality, functional outcome, intracerebral hemorrhage (ICH) volume, and hematoma expansion (HE) between non-vitamin K antagonist oral anticoagulation-related ICH ...
Ambler, Gareth, Basir, Ghazala, Boulanger, Marion, Choi, Philip M. C., Cordonnier, Charlotte, CROMIS-2 Collaborators, Dowlatshahi, Dar, Engelter, Stefan T., Ferrigno, Marc, Houben, Rik, Jaeger, Hans R., Jeng, Jiann-Shing, Meretoja, Atte, Parry-Jones, Adrian R., Perry, Luke A., Purrucker, Jan C., Rizos, Timolaos, Sallinen, Hanne, Salman, Rustam Al-Shahi, Schreuder, Floris H. B. M., Seiffge, David J., Shakeshaft, Clare, Sobowale, Oluwaseun A., Staals, Julie, Tanaka, Jun, Traenka, Christopher, Veltkamp, Roland, Werring, David J., Wilson, Duncan, Wu, Teddy Y., Yakushiji, Yusuke, Yeh, Shin-Joe   +31 more
core   +4 more sources