Results 71 to 80 of about 2,519 (184)

Safety and Efficacy of Direct Oral Anticoagulants Versus Vitamin K Antagonists for Cerebrovascular Ischemic Outcomes in Non‐Valvular Atrial Fibrillation: A Systematic Review and Meta‐Analysis

Clinical Cardiology, Volume 49, Issue 4, April 2026.
Direct Oral Anticoagulants (DOACs) were associated With lower rates of cerebrovascular ischemic events and major bleeding compared With Vitamin K antagonists in non‐valvular atrial fibrillation, With similar mortality. These findings support DOACs as the preferred anticoagulant strategy for stroke prevention in contemporary clinical practice.
Anam Nasir, Naqash Anwar, Abdullah Bin Kamran, Ayesha Muhammad, Ali Haider, Muhammad Mubashar, Fatima Tariq, Mostafa Helou, Besher Shami   +8 more
wiley   +1 more source

Female Sex as a Major Risk Factor for Dabigatran‐Induced Esophagitis in Atrial Fibrillation Ablation

Journal of Arrhythmia, Volume 42, Issue 2, April 2026.
Dabigatran‐induced esophagitis occurred in 18.7% of patients undergoing atrial fibrillation ablation. Female sex was identified as an independent predictor of this complication, highlighting the need for careful periprocedural management and preventive strategies in women.
Daiki Saito, Hidehira Fukaya, Takuya Wada, Jun Oikawa, Sho Ogiso, Yusuke Murayama, Tetsuro Sato, Gen Matsuura, Yuki Arakawa, Shuhei Kobayashi, Hironori Nakamura, Naruya Ishizue, Jun Kishihara, Shinichi Niwano, Satoshi Tanabe, Chika Kusano, Junya Ako   +16 more
wiley   +1 more source

Design and rationale for RE-VERSE AD:A phase 3 study of idarucizumab, a specific reversal agent for dabigatran

, 2015
Idarucizumab, a Fab fragment directed against dabigatran, produced rapid and complete reversal of the anticoagulation effect of dabigatran in animals and in healthy volunteers.
Sellke, F., Reilly, Paul A., Wang, B.S., Sellke, Frank, Huisman, M.V., Pollack, C.V., Eikelboom, John, Glund, S., Steiner, T., Reilly, P.A., Dubiel, Robert, Bernstein, Richard, Stangier, Joachim, Huisman, Menno V., Glund, Stephan, Levy, Jerrold H., Weitz, Jeffrey I., Hylek, E., Weitz, J.I., Hylek, Elaine, Kreuzer, J., Dubiel, R., Stangier, J., Steiner, Thorsten, Kamphuisen, Pieter W., Kam, C.W., Kamphuisen, P.W., Eikelboom, J., Bernstein, R., Pollack, Charles V., Kreuzer, Joerg, Wang, Bushi, Kam, Chak-Wah, Levy, J.H.   +33 more
core   +1 more source

Measuring Direct Oral Anticoagulant (DOAC) Levels: Applications, Limitations, and Future Directions

International Journal of Laboratory Hematology, Volume 48, Issue 2, Page 250-258, April 2026.
ABSTRACT Introduction There are important challenges with the measurement and interpretation of direct oral anticoagulant (DOAC) anticoagulant effect including a lack of therapeutic ranges, inaccuracy of routinely available coagulation assays, lack of established thresholds for clinically significant effect, and uncertainty about how to apply the ...
Siraj Mithoowani, Chee Wee Tan, Deborah M. Siegal   +2 more
wiley   +1 more source

Successful intravenous thrombolysis for ischemic stroke after reversal of dabigatran anticoagulation with idarucizumab: a case report

Journal of Medical Case Reports, 2017
Background Non-vitamin K antagonist oral anticoagulants, including dabigatran, are currently widely used for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation.
Sergio Agosti, Laura Casalino, Enrico Rocci, Gabriele Zaccone, Eugenia Rota   +4 more
doaj   +1 more source

Management of major bleeding in patients treated with direct oral anticoagulants: from experience to standardized protocols

Italian Journal of Medicine, 2020
Evaluation of clinical-laboratory-therapeutic management and related clinical outcomes (thrombotic-hemorrhagic complications) of patients undergoing treatment with direct oral anticoagulants (DOACs) during major bleeding. This is a two-year observational
Sara Mascia, Anna Maria Ferrari, Nicola Macarone Palmieri, Elisa Romagnoli, Chiara Catena, Serena Scarabottini, Francesca Mori, Lucio Brugioni   +7 more
doaj   +1 more source

Non-Vitamin K Oral Anticoagulants Associated Bleeding and Its Antidotes [PDF]

Journal of Stroke, 2018
Oral anticoagulant-associated intracerebral hemorrhage (OAC-ICH) accounts for nearly 20% of all ICH. The number of patients with an indication for oral anticoagulant therapy (OAT) increases with increasing age.
Thorsten Steiner, Martin Köhrmann, Peter D. Schellinger, Georgios Tsivgoulis   +3 more
doaj   +1 more source

Asundexian Versus Apixaban in Patients With Atrial Fibrillation

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Anticoagulation therapy is central to the prevention of thromboembolic disorders but is limited by bleeding complications associated with traditional agents such as warfarin and direct oral anticoagulants (DOACs). Factor XIa inhibition has emerged as a novel strategy aimed at reducing thrombotic risk while preserving hemostasis ...
Zara Saeed, Syeda Ariba Zehra, Sumyya Tariq, Rocio Pun Zumaran, Mounika Kotte, Zeeshan Hameed, Neeraj Joshi, Pushpa Kumari, Kanta Kumari, Awais Habib, Fawad Talat, Osama Taj, Jahanzeb Malik, Abida Perveen   +13 more
wiley   +1 more source

Dabigatran Concentrations in an Actively Breastfeeding Mother–Infant Dyad: Extending the Evidence for Oral Thromboprophylaxis Postpartum

American Journal of Hematology, Volume 101, Issue 7, Page 1628-1631, July 2026.
Rasmus W. Green, Aljona Saleh, Pawel Baranczewski   +2 more
wiley   +1 more source

Neck‐vein thrombosis during spaceflight

British Journal of Clinical Pharmacology, Volume 92, Issue 1, Page 24-34, January 2026.
Spaceflight imposes unique environmental challenges, including weightlessness, increased radiation exposure and confinement, which can lead to unexpected health effects. One such example is neck‐vein thrombosis, a condition rarely seen on Earth without predisposing factors such as venous catheters or infections.
Ulrich Limper, Jens Jordan
wiley   +1 more source