Results 51 to 60 of about 4,737,123 (357)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Does a functioning mind need a functioning body? [PDF]
, 2005 In recent years, the idea that somatic processes are intimately involved in actions traditionally considered to be purely mental has come to the fore. In particular, these arguments have revolved around the concept of somatic markers, i.e., bodily states
Johnson, Colin G.
core
An analysis of the narrowing space of secularism in India and its ramifications in the region
, 2022 Indian society was diverse and complex in nature from its emergence and was marred with communal conflicts. Hence, it was inevitable for the founding fathers of the Indian state to adopt an inclusive political system based on democracy, secularism, and ...
Alam, Sughra +2 more
core +2 more sources
Detecting and Analyzing Botnet Nodes via Advanced Graph Representation Learning Tools
AlgorithmsPrivate consumers, small businesses, and even large enterprises are all at risk from botnets. These botnets are known for spearheading Distributed Denial-Of-Service (DDoS) attacks, spamming large populations of users, and causing critical harm to major ...
Alfredo Cuzzocrea +2 more
doaj +1 more source
An idea model for distributed Idea Management [PDF]
2010 IEEE International Technology Management Conference (ICE), 2010 Processes of Open Innovation and innovation in Living-Labs applying the co-creation paradigm do involve many participating innovators across different organisations and stakeholder groups. This is especially true when dealing with disruptive or radical innovations instead of incremental ones.
Duin, Heiko +3 more
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Vitae, 2014 Antecedentes: Las microalgas son fuente de compuestos fisiológicamente activos que pueden ser usados como ingredientes funcionales. De las microalgas del género Arthrospira (Spirulina) perteneciente a las algas verde-azules y cuyas especies más ...
Alexia TORRES +3 more
doaj
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Frontiers in Robotics and AISocial robots are increasingly being utilized to address mental health challenges in older adults, such as depression, anxiety, and loneliness. However, ethical concerns surrounding their use are insufficiently explored in empirical research.
Lillian Hung +4 more
doaj +1 more source
Southern Spaces, 2008 This excerpt from the 2005 Community Ideas Station film, Rising Up, depicts challenges to segregated spaces in 1960 Richmond, Virginia.
Community Idea Stations
doaj +1 more source