Results 71 to 80 of about 2,900,589 (294)

Staging of amyloid β, t‐tau, regional atrophy rates, and cognitive change in a nondemented cohort: Results of serial mediation analyses

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2018
Introduction Current models posit a sequence of amyloid β (Aβ), tau, atrophy, and cognitive change leading to Alzheimer's disease, but ambiguities remain. We examined these sequences via serial mediations.
Evan Fletcher, Teresa Jenica Filshtein, Danielle Harvey, Alice Renaud, Dan Mungas, Charles DeCarli, Alzheimer's Disease Neuroimaging Initiative   +6 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

How can equity, diversity, and inclusion (EDI) principles be incorporated into research excellence with industry and community partners? Lessons learned from Canada and Australia on projects with a dementia focus

Research Involvement and Engagement
Background The rapid advancement of gerontechnology, technologies for older adults, needs a collaboration that integrates the efforts of researchers, industry and community partners.
Lillian Hung, Karen Lok Yi Wong, Tshepo Rasekaba, Lily Haopu Ren, Dan Douglass, Sandra Slatter, Annette Berndt, Irene Blackberry   +7 more
doaj   +1 more source

A Cloud-Based Multidimensional Big Data Framework for Healthcare Analytics: Bridging OLAP and Cognitive Insights in Chronic Pain Management

Big Data and Cognitive Computing
By considering the real-life research project Pain-RELife, which focuses attention on big data management and analytics tools over patients suffering from chronic pain, located in the Region Lombardy of North Italy, this paper provides a relevant journey
Alfredo Cuzzocrea, Abderraouf Hafsaoui
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Evaluating governance in a clinical and translational research organization

Journal of Clinical and Translational Science
Institutional Development Awards for Clinical and Translational Research (IDeA-CTR) networks, funded by NIH/NIGMS, aim to advance CTR infrastructure to address historically unmet state and regional health needs.
Ingrid Philibert, Amanda Fletcher, Katrina M. Poppert Cordts, Matthew Rizzo   +3 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Expectations of a virtual reality program for older adults with dementia in hospitals: Perspectives of patient partners, families, staff, and care leaders

Digital Health
Background Emerging evidence suggests that virtual reality (VR) technology can potentially improve the wellbeing of older adults living with dementia in hospital care units.
Lily Haopu Ren, Grace Yaqian Liu, Julia Nolte, Catherine Wu, Sena Kholmatov, Jim Mann, Christine Wallsworth, Lily Wong, Kennedy Schaffner, W. Ben Mortenson, Angelica Lim, Jennifer Boger, Lillian Hung   +12 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source