Results 91 to 100 of about 8,022,606 (207)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Taxing capital? : not a bad idea after all! [PDF]
, 2005 In this paper we quantitatively characterize the optimal capital and labor income tax in an overlapping generations model with idiosyncratic, uninsurable income shocks, where households also differ permanently with respect to their ability to generate ...
Conesa, Juan Carlos +2 more
core +3 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
The Individual Mandate: The Ultimate Conservative Idea [PDF]
, 2013 The individual mandate is perhaps the most contested and least popular provision of the 2010 Affordable Care Act (ACA). The mandate, which requires most Americans to obtain health insurance or pay a penalty, was put in the ACA as a means to increase the ...
Ellwanger, Erin
core +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Shaping tomorrows: the CCS as agents of change in Europe’s transition
Frontiers in CommunicationThis article explores the role of the Cultural and Creative Sectors (CCS) as systemic enablers of the European Union’s (EU) triple transition—green, digital and just.
Eva De Smedt, Isabelle De Voldere
doaj +1 more source
DCC: Attractive Idea Seeks Serious Confirmation
, 1996 The theoretical ideas relevant for the physics of the disoriented chiral condensate (DCC) are reviewed.Comment: 18 pages LaTex, based on invited lecture given by A.Krzywicki at the workshop "Quark, plasma and beyond", Zif, Bielefeld, May 1996 ; a ...
Blaizot, J. -P., Krzywicki, A.
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
SWA: SoftWare for Analog Design Automation
ChipsWe have developed SWA: SoftWare for Analog design automation. Its commands can describe analog and mixed-signal (AMS) layouts and schematics to replace the graphic editor with a program reflecting the knowledge of design experts.
Hidekana Susa +3 more
doaj +1 more source