Results 81 to 90 of about 2,900,589 (294)

The Idea of Waste: On the Limits of Human Life

open access: yes
An exploration of both the reality and the spectre of waste throughout history. The Idea of Waste starts with the premise that waste is inevitable in human society.
Scanlan, John
core   +3 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

open access: yesFEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Early brain loss in circuits affected by Alzheimer’s disease is predicted by fornix microstructure but may be independent of gray matter

open access: yesFrontiers in Aging Neuroscience, 2014
In a cohort of community-recruited elderly subjects with normal cognition at initial evaluation, we found that baseline fornix white matter microstructure was significantly correlated with early volumetric longitudinal tissue change across a region of ...
Evan eFletcher   +5 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

open access: yesFEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés   +2 more
wiley   +1 more source

Idea del No [PDF]

open access: yes, 2014
Este trabajo analiza la figura del sujeto imaginario de la poesía de Idea Vilariño y trata de discernirlo no sólo en todos los enunciados que dicen "yo" en el poema, sino también en este "otro yo" que se nombra en el diario y a la vez se escande dual en ...
Monteleone, Jorge Jose
core   +1 more source

Idea Generation and the Quality of the Best Idea

open access: yesManagement Science, 2008
In a wide variety of settings, organizations generate a number of possible solutions to a problem—ideas—and then select a few for further development. We examine the effectiveness of two group structures for such tasks—the team structure, in which the group works together in time and space, and the hybrid structure, in which individuals first work ...
Karan Girotra   +2 more
openaire   +4 more sources

Comparing the paths of Hedgehog release in artificial and natural settings

open access: yesFEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

NIMBY (IDEA Design Excellence Awards)

open access: yes, 2006
WINNER of the Australian IDEA Design Awards Category: Concept - Project : Nimby IDEA, the (inside) Design Excellence Awards, is Australia's most prestigious interdisciplinary awards, celebrating design that changes the way we think, live and interact ...
Minnaert, F
core  

Employee innovation: The roles of idea generation and idea implementation [PDF]

open access: yes, 2000
This study tested the hypothesis that motivation, job competence and creative personality indirectly influenced innovation via idea generation. Results showed that the effects of creative personality and motivation on innovation were, indeed, mediated ...
Unsworth, Kerrie L.   +2 more
core  

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