Results 81 to 90 of about 4,737,123 (357)

How can equity, diversity, and inclusion (EDI) principles be incorporated into research excellence with industry and community partners? Lessons learned from Canada and Australia on projects with a dementia focus

Research Involvement and Engagement
Background The rapid advancement of gerontechnology, technologies for older adults, needs a collaboration that integrates the efforts of researchers, industry and community partners.
Lillian Hung, Karen Lok Yi Wong, Tshepo Rasekaba, Lily Haopu Ren, Dan Douglass, Sandra Slatter, Annette Berndt, Irene Blackberry   +7 more
doaj   +1 more source

Evaluating governance in a clinical and translational research organization

Journal of Clinical and Translational Science
Institutional Development Awards for Clinical and Translational Research (IDeA-CTR) networks, funded by NIH/NIGMS, aim to advance CTR infrastructure to address historically unmet state and regional health needs.
Ingrid Philibert, Amanda Fletcher, Katrina M. Poppert Cordts, Matthew Rizzo   +3 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Expectations of a virtual reality program for older adults with dementia in hospitals: Perspectives of patient partners, families, staff, and care leaders

Digital Health
Background Emerging evidence suggests that virtual reality (VR) technology can potentially improve the wellbeing of older adults living with dementia in hospital care units.
Lily Haopu Ren, Grace Yaqian Liu, Julia Nolte, Catherine Wu, Sena Kholmatov, Jim Mann, Christine Wallsworth, Lily Wong, Kennedy Schaffner, W. Ben Mortenson, Angelica Lim, Jennifer Boger, Lillian Hung   +12 more
doaj   +1 more source

Early brain loss in circuits affected by Alzheimer’s disease is predicted by fornix microstructure but may be independent of gray matter

Frontiers in Aging Neuroscience, 2014
In a cohort of community-recruited elderly subjects with normal cognition at initial evaluation, we found that baseline fornix white matter microstructure was significantly correlated with early volumetric longitudinal tissue change across a region of ...
Evan eFletcher, Owen eCarmichael, Owen eCarmichael, Ofer ePasternak, Klaus H Maier-Hein, Charles eDeCarli   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Idea Generation and the Quality of the Best Idea

Management Science, 2009
In a wide variety of settings, organizations generate a number of possible solutions to a problem—ideas—and then select a few for further development. We examine the effectiveness of two group structures for such tasks—the team structure, in which the group works together in time and space, and the hybrid structure, in which individuals first work ...
Karan Girotra, Christian Terwiesch, Karl T. Ulrich   +2 more
openaire   +4 more sources