Results 41 to 50 of about 412,613 (258)

Diversity in Foresight: a Practice of Selection of Innovation Ideas [PDF]

open access: yesForesight and STI Governance, 2010
The paper investigates an experience of accounting a range of diverse viewpoints when dealing with major objectives of Foresight — priority-setting, networking and consensual vision-building. The relevant practice has a special meaning in contexts characterized by technological discontinuities and high uncertainties.The basic method in this case is the
Ville Brummer, Totti Konnola, Ahti Salo
openaire   +2 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

A Novel Artificial Bee Colony Approach of Live Virtual Machine Migration Policy Using Bayes Theorem

open access: yesThe Scientific World Journal, 2013
Green cloud data center has become a research hotspot of virtualized cloud computing architecture. Since live virtual machine (VM) migration technology is widely used and studied in cloud computing, we have focused on the VM placement selection of live ...
Gaochao Xu   +4 more
doaj   +1 more source

Adaptasi dan Validasi Alat Ukur Perilaku Inovatif Karyawan

open access: yesPsympathic: Jurnal Ilmiah Psikologi, 2020
The growth of the hotel business is increasing, along with the development of tourism. This condition encourages hoteliers to compete to advance their business with a variety of service innovation processes.
Iffah Rosyiana   +3 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Limits of Computational Selection and Their Implications for Human–AI Divergence in Convergent Creativity

open access: yesInformation
This study investigated whether humans and generative Large Language Models (LLMs) exhibit similar performance in divergent ideation but diverge in convergent selection.
Sungwook Jung, Ken Nah
doaj   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

open access: yesFEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino   +2 more
wiley   +1 more source

A fuzzy decision support model for selecting and prioritising improvement initiatives in the context of operational excellence: Application to a mining company

open access: yesScientific African
In today's industrial environment, companies are constantly seeking to improve their operational performance and strengthen their competitiveness. However, selecting and prioritising improvement initiatives remains a complex task for decision-makers ...
Nidal Mansouri   +2 more
doaj   +1 more source

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