Results 71 to 80 of about 413,198 (258)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
UNIVERSITY INNOVATIVE TECHNOLOGIES
Литьë и металлургия, 2012 Methods of selection and appraisal of own technology (product, service, idea) which reflects its readiness for commercialization are offered.
V. G. Kucherov
doaj
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
The concept of internal selection and the subjection of Evolutionary Developmental Biology to the variational model of explanation [PDF]
Biotemas, 2008 The idea of internal selection, originally proposed by Lancelot Whyte, not only helps us to understand the causal status of developmental constraints, but can also show us how these organismic or internal factors, whose relevancy Evolutionary ...
Gustavo Caponi
doaj
Rapid Automatic Motor Encoding of Competing Reach Options
Cell Reports, 2017 Mounting neural evidence suggests that, in situations in which there are multiple potential targets for action, the brain prepares, in parallel, competing movements associated with these targets, prior to implementing one of them.
Jason P. Gallivan +4 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Selección interna: el control de la filogenia por la ontogenia en una perspectiva variacional
Theoria, 2009 La idea de selección interna, propuesta originalmente por Lancelot Whyte, no sólo sirve para entender el papel causal que los constreñimientos del desarrollo tienen en evolución; sino que además puede hacernos comprender de qué modo esos factores ...
Gustavo Caponi
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Interação em Psicologia, 2017 This paper is a reflection on the idea according to which there is a kind of selection dedicated to cultural practices. I will argue that this proposal was based upon a metaphorical extension of natural selection to the cultural dimension.
Diego Zilio
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