Results 111 to 120 of about 7,408,822 (366)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Ideal near-field thermophotovoltaic cells

, 2015
We ask the question, what are the ideal characteristics of a near-field thermophotovoltaic cell? Our search leads us to a reformulation of near-field radiative heat transfer in terms of the joint density of electronic states of the emitter-absorber pair ...
Jacob, Zubin, Molesky, Sean
core   +1 more source

Managerialism: an ideal type

, 2018
Managerialism pervades the higher education literature in much the same way it is said to have pervaded universities themselves. Yet, despite its ubiquity and importance, managerialism remains an under-theorized and elusive concept that has multiple ...
S. Shepherd
semanticscholar   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

La educación y el sentido de la vida

Márgenes
En la actualidad, la sociedad se encuentra inmersa en una fascinación tecnológica que transforma la experiencia humana. El individuo contemporáneo es digital y transhumano, buscando conexión virtual, pero careciendo de contacto humano real.
Ricardo Orellana
doaj   +1 more source

Levinson on the Aesthetic Ideal [PDF]

, 2013
In “Artistic Worth and Personal Taste,” Jerrold Levinson develops a problem for those who think we should strive to be “ideal critics” in our aesthetic lives. He then offers several solutions to this problem.
Riggle, Nicholas
core  

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

A COVID‐19 rapid antigen test employing upconversion nanoparticles

Smart Molecules
The COVID‐19 pandemic has underscored the critical need for rapid and accurate diagnostic tools. Current methods, including Polymerase Chain Reaction and rapid antigen tests (RAT), have limitations in speed, sensitivity, and the requirement for ...
Le Zhang, Jiajia Zhou, Olga Shimoni, Shihui Wen, Amani Alghalayini, Yuan Liu, Meysam Rezaeishahmirzadi, Jiayan Liao, Mahnaz Maddahfar, Roger Hunt, Murdo Black, Matt D. Johansen, Phil M. Hansbro, Lin Zhang, Martina Stenzel, Majid Warkiani, Stella M. Valenzuela, Dayong Jin   +17 more
doaj   +1 more source

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

Molecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva, Bernardo Orr, Ana Azeredo, Andreia Brandão, Manuel R. Teixeira, Paula Paulo   +5 more
wiley   +1 more source

LE CORPS FÉMININ ET SES FLUCTUATIONS DANS LES FLEURS DU MAL ET PETITS POÈMES EN PROSE DE CHARLES BAUDELAIRE [PDF]

Studii si Cercetari Filologice: Seria Limbi Romanice, 2020
Animée d’un souffle splénétique, l’œuvre baudelairienne raconte le corps féminin dans ses multiples fluctuations, partant du corps idéalisé pour sa beauté insolite, jusqu’à sa désacralisation par la souillure du désir charnel et l’emprise du temps.
Saadia RAHALI
doaj