Results 61 to 70 of about 15,093 (264)

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

The behavioural spillover effect: modelling behavioural interdependencies in multi-pathogen dynamics

Journal of Biological Dynamics
During the recent pandemic, a rise in COVID-19 cases was followed by a decline in influenza. In the absence of cross-immunity, a potential explanation for the observed pattern is behavioural: non-pharmaceutical interventions (NPIs) designed and promoted ...
Leah LeJeune, Omar Saucedo, Lauren M. Childs, Navid Ghaffarzadegan   +3 more
doaj   +1 more source

Modeling Without a Gold Standard: Stratification with Stratum-Dependent Parameters

Revstat Statistical Journal, 2014
Bayesian latent-class models have been widely applied for assessing the performance of diagnostic tests in the absence of a gold standard. We provide a short discussion on identifiability issues appearing under the absence of a gold standard, and ...
Francisco Louzada , Gilberto de Araujo Pereira , Márcia M. Ferreira-Silva , Valdirene de Fátima Barbosa , Helio de Moraes-Souza , Gleici S. Castro Perdona   +5 more
doaj   +1 more source

Identifiability of Mixtures

The Annals of Mathematical Statistics, 1961
The class of mixtures of a one-parameter additively-closed family of distributions is proved identifiable. A condition for a class of scale parameter mixtures to be identifiable is indicated and applications to Type III and uniform distributions are made.
openaire   +3 more sources

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen, Ya‐Ting Chang, Levinia Lim, Pai‐Yi Chiu, Jung‐Lung Hsu, SangYun Kim, Wataru Narita, Na Young Ryoo, Kyoko Suzuki, Nagaendran Kandiah, Sebastian Crutch, Ming‐Chyi Pai   +11 more
wiley   +1 more source

Policy-First Architecture for Offline Validation of Emotion-Aware Conversational AI Under Identifiability Constraints

IEEE Access
Adaptive conversational AI systems in high-stakes domains require rigorous architectural validation prior to deployment. However, existing evaluation approaches often fail to distinguish which system-level properties can be reliably assessed under fully ...
Kesara Harisara Punchihewa, Maninda Edirisooriya, Rajkumar Buyya, Lakshika Chandradeva, Achala Aponso   +4 more
doaj   +1 more source

Identifying non-identifiability

, 2018
<em> This is a second post in my series on taming divergences in Stan models, see the first post in the series for a general introduction. Also see guide to Stan warnings </em> <strong> Standard caveat: </strong> <em> I am not an expert on Stan, I consider myself just an advanced user who likes to explain things.
openaire   +1 more source

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen, Stéphane Jean, Weihong Liu, Yihai Dai, Xinrong Fang, Xiaoqiang Wei, Shan Chen, Shiwei Song   +7 more
wiley   +1 more source